{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:12:52Z","timestamp":1783944772056,"version":"3.55.0"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2024AAC05047"],"award-info":[{"award-number":["2024AAC05047"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Science and Technology Department of Ningxia Province","doi-asserted-by":"publisher","award":["2023BCF01028"],"award-info":[{"award-number":["2023BCF01028"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Science and Technology Department of Ningxia Province","doi-asserted-by":"publisher","award":["2022BBF02007"],"award-info":[{"award-number":["2022BBF02007"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Science and Technology Department of Ningxia Province","doi-asserted-by":"publisher","award":["2023BCF01029"],"award-info":[{"award-number":["2023BCF01029"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015811","name":"Science and Technology Department of Ningxia Province","doi-asserted-by":"publisher","award":["2022BBF01003"],"award-info":[{"award-number":["2022BBF01003"]}],"id":[{"id":"10.13039\/100015811","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lactic acid bacteria (LAB) are the main probiotic microorganisms in the human gastrointestinal tract, and their safety in food is recognized globally. Exploring the mechanisms by which LAB mitigate liver injury is crucial for their appropriate application. Alcoholic liver disease (ALD) can be alleviated by improving intestinal epithelial barrier function, controlling lipid metabolism, downregulating inflammatory mediators, and reducing oxidative stress. These mechanisms play important roles in the positive effects of LAB in alleviating liver injury, providing a systematic theoretical basis and practical basis for the clinical application of these bacteria. Future research should focus on transitioning LAB\u2010based interventions for ALD from mechanistic exploration to precision applications. This transition will require a concerted effort in screening functional strains with well\u2010defined molecular targets, developing characterized postbiotic formulations, and rationally designing synergistic symbiotic systems. Nevertheless, the strain\u2010specific effects, potential safety concerns in advanced liver disease, and the need for validation in large\u2010scale, endpoint\u2010driven clinical trials remain significant challenges. To address these challenges, the application of intelligent delivery platforms and multidisciplinary strategies will be critical to achieving the ultimate goal of efficient translation into clinical\u2010grade functional foods.<\/jats:p>","DOI":"10.1002\/mnfr.70489","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:53:21Z","timestamp":1778244801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress in the Application of Lactic Acid Bacteria in Alcoholic Liver Disease"],"prefix":"10.1002","volume":"70","author":[{"given":"Longxuan","family":"Huo","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhai","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qiao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ningxia University  Yinchuan China"},{"name":"Ningxia Key Laboratory of Functional Exploration of Characteristic Agricultural Products and Food Biomanufacturing Ningxia University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines14010049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123259"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010026\u201002679\u20105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072\u2010024\u201010699\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910\u2010023\u201000923\u2010y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.14218\/jcth.2024.00034"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2022.05.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2022.09.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.144463"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5FO02499D"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20107915.70016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405781"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13010074"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5fo00915d"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.107727"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1770833"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05262"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2022.105533"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1372755"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11104-023-06444-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12071341"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205\u2010020\u201002317\u2010y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2023.23393"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2023.2187564"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2024.127711"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14111337"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12436"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13223672"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010023\u201002664\u20107"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109450"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1078447"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2023.2187564"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29030593"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1365074"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c05752"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.146733"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.5455\/OVJ.2025.v15.i8.28"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2025.1672417"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2023.120027"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2024.2395779"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748\u2010605X\/ad6965"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001666\u2010w"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010021\u201011111\u20106"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1212742"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.26599\/fmh.2024.9420020"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.07.030"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060755\u20109"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c03149"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06346"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13182992"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030865"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.01.009"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.115817"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.05.017"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.26599\/fshw.2022.9250172"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2025.2455954"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c06072"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1337439"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1392338"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.103904"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1074286"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1358063"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002283"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4144"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.87664"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1645298"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124381"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i3.100752"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2025.07.577"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366\u20106999.20130744"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:38:26Z","timestamp":1783942706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mnfr.70489"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70489","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70489"}}