{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:04:38Z","timestamp":1783969478190,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015499","name":"Jeonbuk National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015499","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gallic acid (GA), a plant\u2010derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's \u201credox duality\u201d\u2014its capacity to act as either a radical scavenger or a pro\u2010oxidant. In metabolic disorders, GA reprograms cellular machinery by modulating the miR\u2010709\/Nrf2 axis, enhancing LDL clearance via LDLR\/PCSK9, and targeting the incretin system. In oncology, GA exhibits context\u2010dependent toxicity, acting as a selective pro\u2010oxidant to induce apoptosis and synergizing with tyrosine kinase inhibitors (TKIs), though safety interactions require careful assessment. GA's expanded neuropharmacological profile includes mitigating ferroptosis via GPX4 rescue and acting as a positive allosteric modulator of Kv1.1 channels. It also potently inhibits the NLRP3 inflammasome in gouty arthritis. Beyond traditional pharmacology, recent studies highlight GA's emergence in material science, including the development of GA\u2010based Metal\u2010Organic Frameworks (MOFs) and functional hydrogels for osteoarthritis, kidney stone prevention, and wound healing. Despite broad bioactivity, poor bioavailability remains a significant challenge, necessitating innovative bioactive material design and rigorous clinical validation.<\/jats:p>","DOI":"10.1002\/mnfr.70491","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:56:38Z","timestamp":1778244998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential"],"prefix":"10.1002","volume":"70","author":[{"given":"Woo Hyun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical School Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"6789","article-title":"Gallic Acid: A Remarkable Phenolic Compound With Antioxidative Properties","volume":"28","author":"Wianowska D.","year":"2023","journal-title":"Molecules"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408699891274273"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112609"},{"key":"e_1_2_13_6_1","article-title":"Hepatoprotective Effects of Gallic Acid: A Systematic Review of Preclinical Studies","volume":"124","author":"Chen J.","year":"2025","journal-title":"Phytomedicine"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA01911G"},{"key":"e_1_2_13_8_1","first-page":"225","article-title":"Pharmacological Effects of Gallic Acid in Health and Diseases: A Mechanistic Review","volume":"22","author":"Kahkeshani N.","year":"2019","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_13_9_1","first-page":"3306","article-title":"Protective Effects of Antioxidants on Mitochondrial Dysfunction and Cardiovascular Disease","volume":"22","author":"Liobikas J.","year":"2016","journal-title":"Current Pharmaceutical Design"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010023"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237115"},{"key":"e_1_2_13_12_1","first-page":"3927","article-title":"Antioxidant Activity of Gallic Acid and Its Derivatives","volume":"52","author":"Kim S. 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