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Compelling evidence from recent studies underscores a central role for the intestines and their microbiota in mediating interactions between the gut and the liver or the brain. In this article, the effects of polysaccharides from\n                    <jats:italic>Eucommia ulmoides<\/jats:italic>\n                    Oliv. leaves (EULP) on chronic alcoholic tissue injury along the gut\u2013liver or gut\u2013brain axis were studied. Results demonstrated that EULP alleviated gastric mucosal damage, endotoxemia, epithelial tight junction disruption (Occludin and Claudin\u20101), and mucosal barrier dysfunction in CAI mice. Gut microecology analyses indicated that EULP modulates CAI\u2010induced changes in the diversities and abundances of gut microbiota. Furthermore, EULP attenuated chronic alcoholic liver inflammation and oxidative stress, concomitantly improving neurotransmitter secretion while reducing neuroinflammation and oxidative stress in brain tissue. These findings suggest that EULP's ability to alleviate alcohol\u2010induced intestinal epithelial barrier dysfunction and modulate the intestinal microbiota plays a crucial role in the mechanism underlying its amelioration of CAI induced tissue injury at the gut\u2013liver or gut\u2013brain axis.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70497","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:24:32Z","timestamp":1778844272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polysaccharides From\n                    <i>Eucommia ulmoides<\/i>\n                    Oliv. Leaves Could Alleviate Gut Microbiota Dysbiosis and Mitigate Chronic Alcoholic Intoxication in Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Xueping","family":"Leng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources International Institute of Food Innovation Co., Ltd. China\u2010Canada Joint Lab of Food Science and Technology (Nanchang) Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources International Institute of Food Innovation Co., Ltd. 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