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This study investigated its effects on brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues in a diet\u2010induced obesity model. Rats received control (CT\/TUC\u2010), high\u2010fat (HF\/TUC\u2010), control with Tucum\u2010do\u2010Cerrado (CT\/TUC+), or high\u2010fat with Tucum\u2010do\u2010Cerrado (HF\/TUC+) diets. Tucum\u2010do\u2010Cerrado promoted healthier adipose expansion by stimulating adipogenic\/thermogenic\u2010related genes while downregulating lipogenesis. In BAT, HF\/TUC+ attenuated adipocyte hypertrophy and decreased the number of unilocular adipocytes. Tucum\u2010do\u2010Cerrado downregulated\n                    <jats:italic>Fasn<\/jats:italic>\n                    mRNA levels and glutathione peroxidase (GPx) activity, whereas it increased thermogenesis\u2010related\n                    <jats:italic>Ucp1<\/jats:italic>\n                    mRNA. In the iWAT, HF\/TUC+ decreased the adipocyte area and oxidative markers, while increasing the number of multilocular adipocytes and UCP1 protein levels. Tucum\u2010do\u2010Cerrado decreased\n                    <jats:italic>Acaca, Prkaa2<\/jats:italic>\n                    ,\n                    <jats:italic>Il10<\/jats:italic>\n                    mRNA, and GPx activity; conversely, it stimulated the thermogenesis\u2010related genes\n                    <jats:italic>Ppargc1a<\/jats:italic>\n                    and\n                    <jats:italic>Prdm16<\/jats:italic>\n                    . Regarding eWAT, its consumption increased the number of multilocular adipocytes,\n                    <jats:italic>Prkaa1, Ppargc1a, Ucp1<\/jats:italic>\n                    ,\n                    <jats:italic>Prdm16<\/jats:italic>\n                    , and\n                    <jats:italic>Vegfa<\/jats:italic>\n                    mRNA levels, carbonyl levels, and GPx activity, while decreasing\n                    <jats:italic>Acaca<\/jats:italic>\n                    and\n                    <jats:italic>Fasn<\/jats:italic>\n                    mRNA levels. Therefore, Tucum\u2010do\u2010Cerrado prevented adipocyte hypertrophy and increased the number of multilocular adipocytes. The beneficial effects of Tucum\u2010do\u2010Cerrado in an obesity model may be attributed to enhanced antioxidant capacity and inflammatory status, highlighting its potential in attenuating adipose tissue dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70498","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:11:03Z","timestamp":1782850263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tucum\u2010do\u2010Cerrado (\n                    <i>Bactris setosa<\/i>\n                    Mart.) 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