{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:09:42Z","timestamp":1783944582297,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Type 2 diabetes is characterized by chronic dysregulation of insulin signaling, leading to hyperglycemia, hyperinsulinemia, insulin resistance (IR), and obesity. Obesity is associated with alterations in appetite\u2010regulating molecules such as leptin and its receptor, while oxidative stress contributes to disease progression. Curcumin (CUR), a natural antioxidant, may reduce oxidative damage and modulate the expression of molecules involved in appetite regulation and insulin sensitivity under diabetic\u2013obese conditions. To evaluate this, 2\u2010day\u2010old male C57BL\/6 mice were injected with streptozotocin (70\u00a0mg\/kg), maintained on a high\u2010fat diet for 8 weeks, and treated with CUR (50\u00a0mg\/kg) for 4 weeks. Diabetic mice developed hyperglycemia, IR, and obesity, accompanied by decreased glutathione peroxidase activity in visceral (VAT) and brown (BAT) adipose tissues, as well as increased carbonylated protein (PCO) levels in BAT. Additionally, leptin levels were elevated in VAT and plasma, along with increased hypothalamic expression of the leptin receptor b isoform (Lep\u2010Rb). CUR treatment improved peripheral insulin sensitivity and antioxidant activity, reduced PCO levels in BAT, and decreased hypothalamic Lep\u2010Rb expression. These findings suggest that CUR improves insulin sensitivity and redox balance while reducing hypothalamic Lep\u2010Rb expression, suggesting a potential role in restoring energy metabolism, glucose homeostasis, and appetite control in diabetic\u2013obese mice.<\/jats:p>","DOI":"10.1002\/mnfr.70499","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:59:16Z","timestamp":1779087556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin Improves Redox Status and Insulin Sensitivity in the Periphery and Decreases Leptin Receptor Expression in the Arcuate Nucleus in Obese Diabetic Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Yaccil Adilene","family":"Flores\u2010Cortez","sequence":"first","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Mendoza\u2010Bello","sequence":"additional","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Salinas\u2010Bautista","sequence":"additional","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Cortes\u2010Sarabia","sequence":"additional","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Ramirez","sequence":"additional","affiliation":[{"name":"SECIHTI\u2010Faculty of Chemical and Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Lamas","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Cinvestav Sede Sur  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Yareli","family":"Calvario\u2010Pino","sequence":"additional","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1nchez\u2010Alavez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Psychology Autonomous University of Baja California  Tijuana Baja California Mexico"},{"name":"Department of Molecular and Cellular Biology The Scripps Research Institute  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Espinoza\u2010Rojo","sequence":"additional","affiliation":[{"name":"Faculty of Chemical\u2010Biological Sciences Autonomous University of Guerrero  Chilpancingo de los Bravo Guerrero Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001951\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60619-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.59"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.03.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201000978\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45080420"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2017.06.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173328"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201014\u20100405"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2016.1207165"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.002"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.07.019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.101237"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201013\u20101286\u20101_7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2741\/3885"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00056"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14121548"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.151073"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108521"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081837"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266352449250612211106"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937\u2010024\u201001022\u20103"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010016\u20100301\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1552244"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.30.1.64"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3791061"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146325"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20100105.177703"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43088\u2010020\u201000078\u20104"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8609213"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2352361"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349\u20103933.ijam20192224"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.09.004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201016463\u20106"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01638"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103570"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.585887"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010022\u201000712\u20101"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945011794815356"},{"key":"e_1_2_11_41_1","first-page":"278","article-title":"Curcumin and Curcuminoids: Chemistry, Structural Studies and Biological Properties","volume":"81","author":"Gonz\u00e1lez\u2010Albadalejo D.","year":"2015","journal-title":"Anales de la Real Academia Nacional de Farmacia"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122345"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pharmtox\u2010011112\u2010140320"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010167"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112019"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.200974"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020639"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00285.2017"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/187153012799279027"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200716113136"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010236"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u2010091336"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152176"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2024.09.008"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700184"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/jdr\/8050374"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028784"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9071132"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70499","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:22:29Z","timestamp":1783941749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mnfr.70499"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70499","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70499"}}