{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:10:01Z","timestamp":1783944601631,"version":"3.55.0"},"reference-count":131,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["192051"],"award-info":[{"award-number":["192051"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dispersed lipid liquid\u2010crystalline nanoparticles are promising carriers for bioactive compounds in food and pharmaceutical formulations. Ethanol is widely used as a cosolvent and processing aid; however, its direct effect on the internal nanostructure of pre\u2010formed dispersed lipid systems remains poorly understood. Here, we investigate ethanol\u2010induced nanostructural transitions in glycerol monooleate (GMO) and triolein\/GMO dispersions using small\u2010angle x\u2010ray scattering, cryogenic transmission electron microscopy, and dynamic light scattering.<\/jats:p>\n                  <jats:p>In GMO dispersions, increasing ethanol content (lipid\/ethanol weight ratios from 1\/0 to 1\/5) induces structural transitions from inverse bicontinuous cubic (Im3m) phases to sponge phases and, at higher ethanol levels, to structures consistent with direct micelles. In TO\/GMO dispersions (20\/80 to 50\/50), ethanol transforms inverse hexagonal or inverse microemulsion\u2010type structures into sponge\u2010type phases, followed by macroscopic phase separation at elevated ethanol contents. In these phase\u2010separated systems, the aqueous phase contains direct micellar aggregates, whereas the lipid\u2010rich phase retains inverse nanostructures or becomes dominated by triolein\u2010rich domains.<\/jats:p>\n                  <jats:p>These findings demonstrate that ethanol acts as a compositional trigger for nanostructural transitions in dispersed lipid systems and provide mechanistic insight into ethanol\u2010lipid interactions, establishing ethanol responsiveness as a design principle for tunable lipid\u2010based delivery systems.<\/jats:p>","DOI":"10.1002\/mnfr.70502","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:32:14Z","timestamp":1779442334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethanol\u2010Responsive Nanostructures in Glycerol Monooleate\/Triolein Dispersions"],"prefix":"10.1002","volume":"70","author":[{"given":"Parth","family":"Kadakia","sequence":"first","affiliation":[{"name":"Department of Chemistry and Food Research and Innovation Center University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Peterek","sequence":"additional","affiliation":[{"name":"ScopeM ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Salentinig","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Food Research and Innovation Center University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2024.101817"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2019.02.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA12008G"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2020.05.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2008.07.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0927\u20107757(94)02743\u20109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2020.110451"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202100531"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123546"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.06.050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.09.081"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202405131"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00997"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b03902"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.07.031"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.03.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/la305052q"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.07.149"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/la9702188"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091847"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0482711"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.7b03078"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c12125"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/la200591u"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/la503824z"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM00929A"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/la500835e"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302596"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm300646q"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.042"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00153"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303854"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.08.003"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.01.060"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.09.012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010014\u20100277\u20106"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2008.05.024"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2015.06.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160612871"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0SM00491J"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202200446"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.03.089"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/la960318y"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/la970566"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100085a028"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2006.07.003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103097"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2005.12.012"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.072"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952998209002622"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1118761"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2006.11.029"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp711421k"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2fo00005a"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0927\u20107757(96)03628\u2010X"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/la010161w"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/la026404h"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2004.02.027"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf001390b"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927\u20107757(02)00168\u20101"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.106379"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122980"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515708113"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.01.037"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.117683"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0013430"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b06066"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.07.013"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/la026010q"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp808041z"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sm26546j"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2021.105091"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1524\/zpch.2002.216.3.333"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00223a024"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00426a015"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp910897t"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100173a073"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00283a001"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00497a015"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00103a014"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp410305m"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20106997(25)06931\u20105"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107827(88)90010\u20100"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103495(94)80572\u20107"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005\u20102736(85)90248\u20102"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00375a007"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90562-5"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.03.010"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.10.006"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1080\/02678292.2012.719646"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2016.03.005"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP06696H"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp804668n"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/la00021a016"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123893"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp2006467"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.10.017"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127660"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125321"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP02716C"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20103659(99)00222\u20109"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107258(88)90109\u2010X"},{"key":"e_1_2_10_105_1","first-page":"299","article-title":"Identification of lyotropic liquid crystalline mesophases","volume":"2","author":"Hyde S. T.","year":"2001","journal-title":"Handbook of applied surface and colloid chemistry"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3060069"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010067107182"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1678153"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104211"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142\u20109612(99)00126\u2010X"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0CP01029D"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100347a067"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2019.01.124"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.56.608"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1209\/0295\u20105075\/11\/3\/008"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM02634C"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b01356"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR00882C"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.12.125"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00657310"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jciso.2023.100077"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.453006"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SM01639D"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1140\/epje\/s10189\u2010023\u201000337\u2010z"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0sm00049c"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1107\/S002188988201259X"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889895005292"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u20108686(97)00312\u20106"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b06704"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927\u20107757(03)00304\u20102"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0499416"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010020\u201000828\u2010y"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70502","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70502","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:22:36Z","timestamp":1783941756000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":131,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mnfr.70502"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70502","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70502"}}