{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:10:07Z","timestamp":1783944607809,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205151"],"award-info":[{"award-number":["82205151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC3507401"],"award-info":[{"award-number":["2024YFC3507401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study investigated the association between dietary magnesium intake and all\u2011cause and cause\u2011specific mortality among individuals with chronic neck pain (CNP). We enrolled 2955 CNP patients aged \u226520 years from the 1999\u20132020 NHANES database and used Cox regression, subgroup analysis, and Mendelian randomization\u2011based mediation analysis to explore relevant associations and mechanisms. During follow\u2011up, 719 all\u2011cause deaths, 180 cardiovascular disease (CVD) deaths, and 179 cancer deaths occurred. Multivariable\u2011adjusted analyses showed that higher dietary magnesium intake was significantly associated with reduced CVD mortality, with each 1\u00a0g\/day increment linked to a 78% lower risk. A non\u2011linear association with a threshold of 0.5181\u00a0g\/day was found for cancer mortality, above which mortality risk dropped significantly. Subgroup analyses confirmed result robustness. Mediation analysis revealed that magnesium lowered all\u2011cause and CVD mortality directly and indirectly by reducing C\u2011reactive protein (CRP) levels. These findings indicate that higher dietary magnesium intake predicts lower mortality risk in CNP patients, partly via CRP\u2011mediated anti\u2011inflammatory pathways, supporting dietary magnesium optimization from whole\u2011food sources to improve long\u2011term prognosis.<\/jats:p>","DOI":"10.1002\/mnfr.70503","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:54:54Z","timestamp":1779087294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Analysis Between Dietary Magnesium Intake and All\u2010Cause and Cause\u2010Specific Mortality in Individuals With Chronic Neck Pain"],"prefix":"10.1002","volume":"70","author":[{"given":"Renkun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Spine Wangjing Hospital of China Academy of Chinese Medical Sciences  Beijing 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