{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:07:05Z","timestamp":1784038025530,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wild\n                    <jats:italic>Laurus nobilis<\/jats:italic>\n                    fruits, a well\u2010known dietary plant, have been documented to alleviate cardiopathy associated with pulmonary fibrosis, but the underlying mechanisms remain largely unspecified. This current study aimed to investigate the potential therapeutic effects of wild\n                    <jats:italic>L. nobilis<\/jats:italic>\n                    fruits aqueous extract (LNAE) in mitigating pulmonary fibrosis\u2010induced cardiopathy (PFC) in the bleomycin (BLEM) model. Six groups of male rats were included: control, BLEM\u2010treated group, LNAE\u2010treated (25, 50, and 100\u00a0mg\/kg followed by BLEM), and gallic acid. In PFC, instillation of BLEM resulted in a significant increase in relative heart weight, associated with a marked elevation in creatine phosphokinase and lactate dehydrogenase activities, as well as increased plasma levels of blood troponin, pro\u2010brain natriuretic peptide (pro\u2010BNP), and CRP. However, treatment with LNAE significantly attenuated these alterations. Additionally, exposure to BLEM enhanced oxidative stress, lipo\u2010peroxidation, and the levels of certain intracellular mediators in both plasma and tissue, and caused histological damage in the heart. More importantly, treatments with LNAE improved all these physiological and biochemical parameters. This study highlights the synergistic potential of phytoactive compounds in LNAE to alleviate heart conditions. These findings support the development of plant\u2010based nutritional therapy as a novel strategy for the management of cardiovascular disorders.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70504","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:42:13Z","timestamp":1779961333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional Composition and Potential Actions of Bioactive Compounds From Wild\n                    <i>Laurus nobilis<\/i>\n                    in the Management of Pulmonary Fibrosis\u2010Induced Cardiopathy in Rats"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-8385","authenticated-orcid":false,"given":"Saber","family":"Jedidi","sequence":"first","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"},{"name":"National Institute of Technologies and Sciences of Kef (INTeK) University of Jendouba  Kef Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-5480","authenticated-orcid":false,"given":"Ala","family":"Ayari","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4619-6892","authenticated-orcid":false,"given":"Aouar","family":"Abidi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-4098","authenticated-orcid":false,"given":"Houcem","family":"Sammari","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6655-9789","authenticated-orcid":false,"given":"Nourh\u00e8ne","family":"Dhawefi","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-1401","authenticated-orcid":false,"given":"Hichem","family":"Sebai","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Physiology and Valorization of Bio\u2010Resources University of Jendouba, Higher Institute of Biotechnology of Beja  B\u00e9ja Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7407a1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14010154"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022362"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2016.01023"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.03.060"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1261"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287455"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb4707051"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19148373"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(19)30318\u20103"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants6040042"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010eular.2619"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.13.4.19"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30194012"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2020.1727787"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3308"},{"key":"e_1_2_12_18_1","unstructured":"AOAC Official Methods of Analysis \u201c14th Edition Association of Official Analytical Chemists \u201d (1995)."},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","unstructured":"S. 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