{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:24:10Z","timestamp":1788492250349,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatic diseases pose a major and life\u2010threatening global health challenge. Sesaminol, a sesame\u2010seed lignan with antioxidant and anti\u2010inflammatory properties, was investigated for its ability to combat metabolic dysfunction\u2010associated fatty liver disease (MAFLD) and alcohol\u2010related liver injury. Mice fed a high\u2010fat diet (HFD) or subjected to binge alcohol injury received oral sesaminol to evaluate its protective effects against hepatic dysfunction. Complementary in vitro studies used HepG2 cells to delineate the potential mechanism. Sesaminol reduced body\u2010weight gain, enhanced glucose tolerance and insulin signaling, lowered hepatic and serum lipid accumulation, and attenuated the inflammatory response in mice. Moreover, sesaminol dose\u2010dependently reduced triglyceride (TG) accumulation and suppressed pro\u2010inflammatory cytokines in vitro. Transcriptomic and docking analyses identified peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1) as a direct sesaminol target and revealed solute carrier family 27 member 5 (Slc27a5) as a novel downstream gene. Sesaminol enhanced PPAR\u03b1 occupancy on the\n                    <jats:italic>Slc27a5<\/jats:italic>\n                    promoter, increased fatty acid uptake, and restored mitochondrial \u03b2\u2010oxidation flux. Therefore, sesaminol may function as a natural PPAR\u03b1 agonist that links fatty acid import to mitochondrial oxidation via Slc27a5, thereby ameliorating hepatic steatosis and inflammation in both metabolic and alcohol\u2010related liver dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70506","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:34:02Z","timestamp":1779442442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sesaminol Ameliorates Metabolic and Alcohol\u2010Related Liver Injury by Activating the PPAR\u03b1\/Slc27a5 Axis\u2010Driven Hepatic Fatty Acid \u03b2\u2010Oxidation"],"prefix":"10.1002","volume":"70","author":[{"given":"Liujie","family":"Zheng","sequence":"first","affiliation":[{"name":"College of Biotechnology and Bioengineering Zhejiang University of Technology  Hangzhou 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