{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:10:28Z","timestamp":1783944628122,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["PEN05008"],"award-info":[{"award-number":["PEN05008"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2024\u201067017\u201042459"],"award-info":[{"award-number":["2024\u201067017\u201042459"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010alcoholic fatty liver disease (NAFLD) is a comorbidity of obesity, and sex influences disease progression. Cocoa can mitigate NAFLD, but the impact of sex has never been investigated. Herein, we compared the hepatoprotective effects of cocoa with different processing histories (unfermented\/unroasted, unfermented\/roasted, fermented\/unroasted, fermented\/roasted) in obese male and female mice. C57BL\/6J mice were fed a high\u2010fat diet (HFD) for 8 weeks to induce obesity and then randomized to HFD or HFD supplemented with 80\u00a0mg cocoa\/g diet for an additional 8 weeks. Hepatic responses were analyzed at the mRNA and protein levels. Cocoa\u2010treated male mice had decreased liver weight and enhanced expression of mitochondrial oxidative and endoplasmic reticulum (ER) stress response markers (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Cocoa\u2010treated female mice had lower ER stress response markers and increased markers of very low\u2010density lipoprotein biogenesis compared to HFD\u2010fed controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Two\u2010way multivariate analysis of variance revealed significant main effects of sex and diet, and a significant interaction. Canonical variate analysis demonstrated the efficacy of fermented\/unroasted and fermented\/roasted cocoas in both sexes, and unfermented\/unroasted and unfermented\/roasted cocoas in females. Cocoa mitigated obesity\u2010related NAFLD by sexually dimorphic mechanisms. Further research is needed to develop personalized nutritional recommendations incorporating cocoa.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70508","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:30:54Z","timestamp":1779442254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Specific Effects of Cocoa on Hepatic Redox Regulation and Lipid Homeostasis in High\u2010Fat Diet\u2010Fed Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Juhui","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Food Science The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Sotzen","sequence":"additional","affiliation":[{"name":"The Integrative and Biomedical Physiology Intercollege Graduate Degree Program The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne K.","family":"Weikart","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2010Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumble Sandeep","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences The Pennsylvania State University University Park  Pennsylvania USA"},{"name":"The Center of Molecular Toxicology and Carcinogenesis The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University University Park  Pennsylvania USA"},{"name":"The Center of Molecular Toxicology and Carcinogenesis The Pennsylvania State University University Park  Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0239"},{"key":"e_1_2_8_3_1","first-page":"116","article-title":"Role of Oxidative Stress in the Pathogenesis of Nonalcoholic Fatty Liver Disease","volume":"152","author":"Chen Z.","year":"2020","journal-title":"Biology and 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