{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:14:03Z","timestamp":1787613243529,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"publisher","award":["YXJL\u20102022\u20100734\u20100294"],"award-info":[{"award-number":["YXJL\u20102022\u20100734\u20100294"]}],"id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal fibrosis, a pivotal pathological process in chronic kidney disease (CKD), is closely associated with inflammatory responses and gut microbiota dysbiosis. Curcumin (CUR), a natural polyphenol derived from turmeric, shows anti\u2010inflammatory and microbiota\u2010modulating properties. However, its potential to attenuate renal fibrosis via gut microbiota\u2010derived metabolites remains unclear. In this study, we investigated the mechanisms underlying the renoprotective effects of CUR, using a murine model of unilateral ureteral obstruction and LPS\u2010stimulated bone marrow\u2010derived macrophages (BMDMs). CUR treatment significantly alleviated renal interstitial fibrosis, reduced collagen deposition, and downregulated the pro\u2010inflammatory mediators S100 calcium\u2010binding proteins A8 (S100A8)\/A9. Additionally, CUR modified the gut microbiota composition by enriching short\u2010chain fatty acid (SCFA)\u2010producing bacteria, leading to elevated systemic SCFA levels, particularly acetate, whose supplementation also ameliorated renal fibrosis, suppressed the S100A8\/A9\u2013toll\u2010like receptor 4 (TLR4)\/nuclear factor kappa\u2010B (NF\u2011\u03baB) signaling axis, and inhibited macrophage\u2013myofibroblast transition (MMT). Acetate in vitro treatment attenuated the LPS\u2010induced co\u2010expression of S100A8\/A9 and TLR4 in BMDMs, reduced pro\u2010inflammatory cytokine release, and suppressed M1 polarization. These findings highlight that acetate, a key microbiota\u2010derived metabolite increased by CUR treatment, mediates renal protection by targeting the S100A8\/A9\u2010TLR4 signaling pathway in macrophages, suggesting a novel gut\u2013kidney axis\u2010based therapeutic strategy for CKD.<\/jats:p>","DOI":"10.1002\/mnfr.70521","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:33:54Z","timestamp":1780911234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin Inhibits Renal Fibrosis by Suppressing S100A8\/A9\u2010TLR4 Signaling via Gut Microbiota\u2010Derived Short\u2010Chain Fatty Acid in Macrophages"],"prefix":"10.1002","volume":"70","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Kidney Transplantation Nephropathy Hospital the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 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