{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:06:36Z","timestamp":1784037996835,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tectochrysin (TEC), a natural flavonoid, has shown efficacy in ameliorating chronic colitis. However, its therapeutic potential in colitis\u2010associated colon cancer (CAC) remains unclear. This study aimed to investigate the interventional effects of TEC on an AOM\/DSS\u2010induced mouse CAC model and elucidate its underlying molecular mechanisms. The CAC mice model was established by induction with AOM\/DSS. Mice were treated with TEC and\/or the\n                    <jats:italic>Drp1<\/jats:italic>\n                    inhibitor Mdivi\u20101. Western blot, qRT\u2010PCR, transmission electron microscopy, immunofluorescence, and luciferase reporter assays were employed to assess mitophagy activation and related signaling pathways. TEC significantly alleviated CAC progression, as evidenced by reduced tumor burden, disease activity index, and weight loss. It activated mitophagy in intestinal epithelial cells (IECs) via the\n                    <jats:italic>Pink1<\/jats:italic>\n                    \/\n                    <jats:italic>Parkin<\/jats:italic>\n                    pathway and reversed Mdivi\u20101\u2010induced mitophagy inhibition. Tectochrysin ameliorates CAC by activating IEC mitophagy, highlighting its potential as a therapeutic agent for CAC.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70524","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:49:16Z","timestamp":1780476556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tectochrysin Ameliorates Colitis\u2010Associated Colon Cancer in Mice Via the Activation of Mitophagy in Intestinal Epithelial Cells"],"prefix":"10.1002","volume":"70","author":[{"given":"Jikai","family":"He","sequence":"first","affiliation":[{"name":"Department of General Hepatobiliary Surgery Zhoushan Hospital Wenzhou Medical University  Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanmei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Zhoushan Hospital Wenzhou Medical University  Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Zhoushan Hospital Wenzhou Medical University  Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of General Hepatobiliary Surgery Zhoushan Hospital Wenzhou Medical University  Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Hepatobiliary Surgery Zhoushan Hospital Wenzhou Medical University  Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010025\u201001698\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113642"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.104110"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2259214"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412551"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79876"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1448878"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500813R"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.028"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216621"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c09132"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102760"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010022\u201003642\u2010x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111773"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010024\u201000915\u20107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201005061\u20107"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020480"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300283"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020205"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14294"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113092"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026295\u20108"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010023\u201000458\u20105"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322512"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.117086"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578\u2010022\u201000935\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010021\u201002382\u2010x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.2007027"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101925"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001503\u20107"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084862"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae007"}],"container-title":["Molecular Nutrition &amp; 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