{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:06:35Z","timestamp":1784037995853,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity\u2010induced cognitive decline involves chronic inflammation and neuronal dysfunction. This study investigated the mechanistic associations of probiotic\u2010fermented\n                    <jats:italic>Aronia melanocarpa<\/jats:italic>\n                    extract (LAB\u2010A) on metabolic and cognitive dysfunction in high\u2010fat diet (HFD)\u2010fed mice. Fermentation doubled total polyphenol content and increased aglycones like quercetin and eriodictyol. LAB\u2010A attenuated microglial neuroinflammation by inhibiting NF\u2010\u03baB translocation (94.4% reduction,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and protected neurons from apoptosis by reducing the BAX\/BCL\u20102 ratio (89.3%,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). In HFD\u2010fed mice, LAB\u2010A significantly reduced weight gain and improved lipid\/hepatic profiles (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Behaviorally, LAB\u2010A significantly ameliorated cognitive deficits, improving recognition and spatial memory (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). At the molecular level, LAB\u2010A suppressed hippocampal NF\u2010\u03baB, restored AMPK\u03b1 phosphorylation, and markedly upregulated BDNF (\u223c11.0\u2010fold,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). These changes were accompanied by reinforced blood\u2013brain barrier (BBB) integrity, as evidenced by a 3.1\u2010fold increase in Occludin (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Fermentation enhances the bioactivity of\n                    <jats:italic>Aronia<\/jats:italic>\n                    by increasing aglycone\u2010type phenolics. LAB\u2010A effectively mitigates obesity\u2010related metabolic and cognitive dysfunction, associated with coordinated modulation of the AMPK\u03b1\/NF\u2010\u03baB\/BDNF axis and reinforcement of BBB integrity, highlighting its potential as a functional food ingredient for obesity\u2010associated neuroprotection.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70532","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:47:31Z","timestamp":1781506051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fermentation\u2010Induced Phenolic Remodeling of\n                    <i>Aronia melanocarpa<\/i>\n                    Alleviates Obesity\u2010Induced Cognitive Dysfunction Associated With Coordinated Modulation of the AMPK\/NF\u2010\u03baB\/BDNF Axis and BBB Integrity"],"prefix":"10.1002","volume":"70","author":[{"given":"Jisu","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Korea University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition Anyang University  Anyang\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon\u2010Son","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Nutrition Sangmyung University  Seoul Republic of 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