{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:07:45Z","timestamp":1784189265706,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The gut\u2013vaginal axis represents a key frontier in women's health, where probiotics can influence both ecosystems through microbial and metabolic crosstalk. This randomized, double\u2010blind, placebo\u2010controlled clinical trial evaluated the effects of\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    Probio87 (9 log CFU\/sachet) administered orally for 12 weeks on gut and vaginal microbiota modulation. Healthy women aged 18\u201380 years without urogenital infections, pregnancy, recent vaginal\/hormonal therapies, chronic illness medication, and recent pelvic or gynecological surgery were enrolled. 112 participants were randomized to probiotic (\n                    <jats:italic>n<\/jats:italic>\n                    = 58) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    = 54). Vaginal and fecal samples collected at baseline and week 12 underwent 16S rRNA sequencing for taxonomic and diversity analyses. No adverse effects were reported throughout the study. Compared with placebo, the probiotic group showed a significantly greater reduction in Nugent score (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.008), indicating improved vaginal health. Microbiota analyses revealed that Probio87 maintained vaginal microbiota by suppressing BV\u2010associated taxa while preserving beneficial\n                    <jats:italic>Lactobacillales<\/jats:italic>\n                    . In the gut, Probio87 enhanced microbial richness and evenness, with notable increases in butyrate\u2010producing genera, indicating a predicted rise in short\u2010chain fatty acid\u2010producing potential and greater ecological resilience. These findings demonstrate that oral supplementation with Probio87 safely promotes balanced gut and vaginal microbiota, supporting eubiosis and integrative female health.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70535","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:51:10Z","timestamp":1783961470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized, Double\u2010Blind, Placebo\u2010Controlled Trial of the Probiotic\n                    <i>Lactiplantibacillus plantarum<\/i>\n                    Probio87 for Gut\u2013Vaginal Microbiota Modulation in Healthy Women"],"prefix":"10.1002","volume":"70","author":[{"given":"Azka Ainun","family":"Nisaa","sequence":"first","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar Shin","family":"Goh","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Mageswary","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nashriq","family":"Kadir","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Hospital Universiti Sains Malaysia  Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salina","family":"Sany","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Sunway Medical Centre Penang  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engku Husna Engku","family":"Ismail","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Hospital Universiti Sains Malaysia  Kelantan Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Tze","family":"Liong","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010Shun","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azha Syahril","family":"Azizan","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology, Kulliyyah of Medicine Sultan Ahmad Shah Medical Centre International Islamic University Malaysia  Pahang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7298.1327"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3329\/fmcj.v6i1.7403"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.2001.tb01549.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.1.97\u2010101.2003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/511045"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3329\/fmcj.v6i1.7403"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.08.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.297\u2010301.1991"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134608"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037818"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2016.36.5.441"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023558"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102018\u2010000032"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.759156"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010016\u20100368\u2010y"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1922241"},{"key":"e_1_2_10_18_1","first-page":"129","volume":"10","author":"Van de Wijgert J. 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