{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:07:32Z","timestamp":1784189252210,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) is characterized by immune dysregulation and an imbalance in the gut microbiota. Cyanidin\u20103\u2010O\u2010glucoside (C3G), a natural anthocyanin with anti\u2010inflammatory properties, shows therapeutic potential, though its mechanisms remain incompletely defined. This study evaluated the effects of C3G on intestinal inflammation, microbiota, metabolites, and nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling in a dextran sulfate sodium (DSS)\u2010induced colitis model in BALB\/c mice. In vitro RAW264.7 cells were used to assess pathway involvement. Molecular and histological analyses were performed using qRT\u2010PCR, Western blotting, and immunostaining, while microbiota and metabolite profiles were analyzed by 16S rDNA sequencing and UHPLC\/Q\u2010TOF\u2010MS. C3G attenuated colitis severity, improved histological damage, increased interleukin\u201010, and reduced IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 levels. NF\u2010\u03baB activation was inhibited, accompanied by enhanced anti\u2010inflammatory macrophage polarization. C3G also altered gut microbiota composition, reducing pathogenic taxa and enriching beneficial microbes. Metabolomic analysis identified 1\u2010deoxynojirimycin (1\u2010DNJ) as associated with C3G treatment. Overall, C3G modulates inflammatory responses, microbiota composition, and NF\u2010\u03baB signaling in experimental colitis and is associated with changes in 1\u2010DNJ, warranting further mechanistic investigation.<\/jats:p>","DOI":"10.1002\/mnfr.70539","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:26:38Z","timestamp":1783963598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cyanidin\u20103\u2010O\u2010glucoside Alleviates Inflammatory Bowel Disease by Targeting the NF\u2010\u03baB Pathway and is Associated With Alterations in 1\u2010DNJ"],"prefix":"10.1002","volume":"70","author":[{"given":"Zihan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The Affiliated People's Hospital Jiangsu University  Zhenjiang Jiangsu P.R. 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