{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:07:53Z","timestamp":1784189273443,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1) is a key regulator of lipid metabolism and energy homeostasis. However, its role in shaping the gut microbiota requires further investigation. Therefore, the aim of the present study was to investigate whether the lack of PPAR\u03b1 in a mouse model or the presence of a single nucleotide polymorphism (SNP) rs6008259 of PPAR\u03b1 in humans can modulate the gut microbiota and its association with metabolic alterations. PPAR\u03b1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    and PPAR\n                    <jats:sup>+\/+<\/jats:sup>\n                    male mice were fed an AIN\u201093 diet for 10 days, and a human cohort (\n                    <jats:italic>n<\/jats:italic>\n                    = 177) was genotyped for the PPAR\u03b1 SNP rs6008259. PPAR\u03b1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed less body weight gain, more fat mass and reduced lean mass compared to WT, despite similar food intake. They exhibited elevated hepatic triglycerides and hyperlipidemia. In humans, carriers of the rs6008259 allele of PPAR\u03b1 showed similar findings in blood lipids and body composition. Colonic analysis revealed reduced hypoxia in PPAR\u03b1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, increased inflammatory markers, and compromised barrier function. Gut microbiota analysis in PPAR\u03b1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice and humans, carriers of the rs6008259 allele of PPAR\u03b1 showed reduced alpha diversity and altered composition, including increased\n                    <jats:italic>Blautia, Parabacteroides<\/jats:italic>\n                    and\n                    <jats:italic>Lanchoclostridium<\/jats:italic>\n                    . Genetic background is important in the interpretation on the effects of diet on gut microbiota.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70549","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:20:31Z","timestamp":1783963231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PPAR\n                    <sub>\u03b1<\/sub>\n                    Dependent Regulation of Gut Microbiota: Implication for Host Metabolic Homeostasis"],"prefix":"10.1002","volume":"70","author":[{"given":"M\u00f3nica","family":"S\u00e1nchez\u2010Tapia","sequence":"first","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Tob\u00f3n\u2010Cornejo","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Guevara\u2010Cruz","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Vel\u00e1zquez\u2010Villegas","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hern\u00e1ndez\u2010Pando","sequence":"additional","affiliation":[{"name":"Departamento De Patolog\u00eda Experimental Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"L\u00f3pez\u2010Barradas","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Guizar\u2010Heredia","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoniel","family":"Maya","sequence":"additional","affiliation":[{"name":"Physics Department Chalmers University of Technology  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Furuzawa\u2010Carballeda","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda Experimental Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rebollar\u2010Vega","sequence":"additional","affiliation":[{"name":"RED de apoyo a la investigaci\u00f3n Coordinaci\u00f3n de la Investigaci\u00f3n Cient\u00edfica UNAM e Instituto Nacional De Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Vargas\u2010Castillo","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Cell Biology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimbe","family":"Torres","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando R.","family":"Tovar","sequence":"additional","affiliation":[{"name":"Departamento De Fisiolog\u00eda de La Nutrici\u00f3n Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  M\u00e9xico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.08.027"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.05.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00023.2009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R035766"},{"key":"e_1_2_10_6_1","first-page":"2158","article-title":"PPARalpha Polymorphisms Association With Total Cholesterol and LDL\u2010C Levels in a Mexican Population","volume":"26","author":"Ortega\u2010Melendez A. I.","year":"2022","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143516"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1926"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.2.582"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2465896"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2025.101592"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102015\u2010310798"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00153.2019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9949"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(24)00390\u2010X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.05.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14\u201007\u20101194"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2018.1539595"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214156"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1960135"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01628\u201022"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84928-w"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2025.112836"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lipd.12096"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.003798"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14245378"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010008\u20109114\u2010x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010015\u20109766\u2010x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00147.2023"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.2022407"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:43:04Z","timestamp":1784187784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mnfr.70549"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70549","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70549"}}