{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:03:36Z","timestamp":1785308616017,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aspartame is a commonly used sweetener that is increasingly becoming the main source of sweetness in foods due to its low\u2010calorie and high\u2010sweetness characteristics. Excessive intake of aspartame can lead to the occurrence of cardiovascular metabolic diseases and metabolic syndrome, especially hypertension. However, research on the correlation between exposure to aspartame and the development of hypertension remains insufficient. The hypothalamus is the main site regulating blood pressure. Our study established a chronic aspartame exposure model by administering 50\u00a0mg\/kg aspartame water, measured the blood pressure of 4\u2010week\u2010old mice, and analyzed hypothalamic transcriptomic changes through full\u2010length transcriptome sequencing. The results showed that chronic aspartame exposure significantly increased blood pressure in mice (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Full\u2010length transcriptome sequencing identified 630 differentially expressed transcripts between the control and aspartame groups, with enrichment analysis showing significant changes in terms and pathways related to nervous system development and blood pressure. In addition, we found that increased neuronal necrosis in the paraventricular nucleus of the hypothalamus, and the Wnt\/\u03b2\u2010catenin signaling pathway was significantly activated in the aspartame group. In summary, our study suggested that chronic aspartame exposure is associated with elevated blood pressure in mice and affects the development of the hypothalamus at the transcript level.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70563","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:04:05Z","timestamp":1785139445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Aspartame Exposure Leading to Hypertension in Mice may be Related to the Activation of the Wnt\/\u03b2\u2010Catenin Signaling Pathway in the Hypothalamus"],"prefix":"10.1002","volume":"70","author":[{"given":"Wenyu","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education China Medical University  Shenyang Liaoning P.R. China"},{"name":"Child and Adolescent Health, School of Public Health China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education China Medical University  Shenyang Liaoning P.R. China"},{"name":"Child and Adolescent Health, School of Public Health China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education China Medical University  Shenyang Liaoning P.R. China"},{"name":"Child and Adolescent Health, School of Public Health China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education China Medical University  Shenyang Liaoning P.R. China"},{"name":"Child and Adolescent Health, School of Public Health China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education China Medical University  Shenyang Liaoning P.R. China"},{"name":"Child and Adolescent Health, School of Public Health China Medical University  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2025.103296"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.117009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010025\u201000999\u2010w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2025.07.033"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.03.009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102022\u2010071204"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2025.01.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30752\u20102"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14521"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.08.034"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201041213\u20102"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO05553E"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113394"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109373"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2022.01.001"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010025\u201002677\u20103"},{"key":"e_1_2_11_20_1","first-page":"677","article-title":"[The Effects of Aspartame Exposure on the Mechanical Barrier of the Mice Colon]","volume":"59","author":"Xu D.","year":"2025","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05394"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102025\u2010099250"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118500"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13330"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa209"},{"key":"e_1_2_11_26_1","volume-title":"StatPearls","author":"Leslie S. W.","year":"2025"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci12080777"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010013\u20100330\u2010y"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1661836"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107946"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201003\u201000629.2002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1433"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31511"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2025.09.037"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.70497"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.313788"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(96)10508\u20100"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/37123"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0860-4"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201027064\u20102"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014010085"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000205"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.08.004"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.05.001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7241"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105981"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1128594"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab321"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136943"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010020\u201000568\u2010z"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15061467"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70563","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70563","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:23:13Z","timestamp":1785306193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":51,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/mnfr.70563"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70563","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70563"}}