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This study explored the anti\u2010obesity effects of Broussonetia flavonol F (BPF) and its ability to modulate gut microbiota in high\u2010fat diet (HFD)\u2010induced obese mice. After 6 weeks of BPF treatment, obese mice exhibited significant reductions in body weight, adipose tissue mass, and serum lipid levels (TC, TG, and LDL\u2010C), alongside improved glucose tolerance. BPF inhibited fat deposition by downregulating key adipogenic and lipogenic genes in both inguinal adipose tissue (i\u2010WAT) and epididymal adipose tissue (e\u2010WAT). Additionally, BPF improved gut barrier function and reduced TNF\u2010\u03b1 and IL\u20106 levels. 16S rRNA sequencing revealed that BPF restored gut microbiota diversity, increasing the abundance of beneficial bacteria such as Lactobacillus, while decreasing the Firmicutes\/Bacteroidetes ratio, a marker of obesity\u2010related dysbiosis. Mechanistically, the anti\u2010obesity effects of BPF were abolished in antibiotic\u2010treated mice and were reproduced by FMT from BPF\u2010treated donors, confirming a gut microbiota\u2010dependent mechanism. Our findings demonstrate that BPF alleviates obesity by reshaping gut microbiota structure and suppressing metabolic inflammation, highlighting its potential as a therapeutic agent for obesity management.<\/jats:p>","DOI":"10.1002\/mnfr.70564","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:44:31Z","timestamp":1787561071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Broussoflavonol F Alleviates Obesity\u2010Associated Metabolic Syndrome in Obese Mice by Modulating Gut Microbiota"],"prefix":"10.1002","volume":"70","author":[{"given":"Cunzhen","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingya","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Science Xinyang Normal University 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