{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:28:14Z","timestamp":1787120894795,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Phenolic compounds are recognized for antioxidant, anti\u2010inflammatory, and antidiabetic properties. Lentils are abundant in these compounds, yet comparative studies across varieties and intestinal cells effects remain limited. This study evaluated the nutritional composition, phenolic profile, antioxidant activity, and \u03b1\u2010glucosidase inhibition of four lentil types in raw and cooked forms. L01 had the highest bioactive potential and was the only one selected for further evaluation in Caco\u20102 cells under basal and IL\u20101\u03b2\u2010stimulated conditions. Cooking altered composition, leading to higher protein, fiber, and carbohydrates, reducing tannins, and maintaining high phytic acid in some varieties. L01 consistently showed the highest phenolic content, antioxidant activity, and enzyme inhibition. Its phenolic profile was dominated by kaempferol derivatives, (epi)catechin, and procyanidins, with cooking increasing monomeric catechins but reducing procyanidin oligomers. At noncytotoxic levels, L01 extracts reduced IL\u20106\/8 secretion in stimulated cells, with stronger effects from raw extracts. Additionally, they decreased expression of inflammatory markers (IL\u20106\/8\/1\u03b2) while increasing expression of metabolic regulation\u2010 and barrier\u2010related genes (\n                    <jats:italic>Peroxisome proliferator\u2010activated receptor\u2010\u03b3<\/jats:italic>\n                    ,\n                    <jats:italic>Sirtuin 1, Occludin, and Cadherin\u20101<\/jats:italic>\n                    ). Only raw extracts significantly enhanced\n                    <jats:italic>Heme oxygenase\u20101<\/jats:italic>\n                    expression under stimulation. These findings highlight compositional differences beyond tegument color and support further investigation of phenolic\u2010rich lentils as potential functional food ingredients targeting gut and metabolic health.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70572","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:12:56Z","timestamp":1786083176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic\u2010Rich Lentil Extracts Regulate Cytokine Production, Metabolic Pathways and Barrier Function in Intestinal Epithelial Cells"],"prefix":"10.1002","volume":"70","author":[{"given":"Rafaela","family":"Geraldo","sequence":"first","affiliation":[{"name":"Universidade Cat\u00f3lica Portuguesa CBQF\u2010 Centro de Biotecnologia e Qu\u00edmica Fina\u2010 Laborat\u00f3rio Associado, Escola Superior de Biotecnologia Rua Diogo Botelho 1327  Porto 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