{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:18:06Z","timestamp":1787897886462,"version":"build-2784847793"},"reference-count":54,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity in women of reproductive age is often associated with low\u2010grade inflammation and functional iron deficiency. Epigallocatechin gallate (EGCG), a major green tea catechin, has antioxidant, anti\u2010inflammatory, and metabolic\u2010regulating properties but may also interfere with iron absorption. This randomized, double\u2010blind, placebo\u2010controlled pilot study evaluated the effects of EGCG on lipid profile, inflammation, iron status, and plasma metabolomics in women with obesity. Seventeen participants (BMI \u226530\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; age 20\u201344 years) received 400\u00a0mg\/day EGCG (green tea extract: 98% polyphenols, 60% catechins, \u223c50% EGCG) or placebo for eight weeks. Outcomes included serum lipids, inflammatory markers (CRP, IL\u20106, TNF\u2010\u03b1, IL\u201010), iron indices (ferritin, hepcidin, serum iron, transferrin saturation), glucose, and metabolomics. No between\u2010group difference remained significant after correction for multiple comparisons. Total cholesterol (\u03b2 = \u221210.9\u00a0mg\/dL;\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0 = 0.16) and LDL\u2010C (\u03b2 = \u22129.7\u00a0mg\/dL;\u00a0\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0 = 0.16) showed decreases, and IL\u20106 the largest, though nonsignificant, reduction (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0 = 0.09); other cytokines and glucose were unchanged. Metabolomics identified 29 nominally differential metabolites enriched in lipid metabolism, plasmalogen biosynthesis, and mitochondrial \u03b2\u2010oxidation, none surviving FDR correction. Iron status was stable. These findings suggest metabolic effects of EGCG and support short\u2010term safety at 400\u00a0mg\/day. Larger, longer trials with targeted metabolomics are warranted.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70575","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:07:14Z","timestamp":1787119634000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Epigallocatechin Gallate Supplementation on Inflammation, Iron Status, and Metabolomic Profiles in Women With Obesity: A Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"70","author":[{"given":"Sixtus","family":"Aguree","sequence":"first","affiliation":[{"name":"Department of Applied Health Science Indiana University School of Public Health  Bloomington Indiana USA"},{"name":"Department of Food Science and Human Nutrition Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedir N.","family":"Turi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Indiana University School of Public Health  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra R.","family":"Handt","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Kohut","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju B.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.01.014"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20945"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.319"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005439"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6093587"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6093587"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010015\u20101048\u20101"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408690091189194"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.94"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601309"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2008.11.011"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010340"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.6.1698S"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408690390826464"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.10.3275S"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010039"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2010.10719814"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.006"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.11.028"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118136"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01366"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00752.2005"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5923"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201012\u2010280"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114599000537"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1248742"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2010.01.015"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11708"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023426"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdnut.2023.100512"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00354"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2018"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.86"},{"key":"e_1_2_13_36_1","unstructured":"Team R.C. 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