{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:18:06Z","timestamp":1787897886023,"version":"build-2784847793"},"reference-count":162,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The ketogenic diet (KD), characterized by very low carbohydrate intake, moderate protein consumption, and variable fat content depending on the specific dietary protocol, has emerged as a promising metabolic approach in oncology. Although significant progress has been achieved in chemotherapy and immunotherapy for cancer treatment, it still faces challenges in terms of resistance to drugs, systemic toxicity, and immunosuppressive microenvironments of tumor tissues. The KD has been reported to exploit the metabolic weaknesses of tumor cells, such as glycolytic addiction and mitochondrial rigidity, while sparing normal tissue metabolism. The anticancer effects of KD are linked to metabolic and signaling reprogramming that may increase tumor sensitivity to treatment. The ketone bodies, especially \u03b2\u2010hydroxybutyrate, play a significant role in tumor metabolism and stress response through histone deacetylase inhibition, anti\u2010inflammatory properties in normal tissues, and modulation of chemotherapy\u2010induced toxicity. A large body of preclinical data supports the use of KD to enhance the efficacy of chemotherapeutic agents, such as cisplatin, doxorubicin, temozolomide, and gemcitabine, through mechanisms that include redox imbalance, inhibition of DNA repair, and induction of apoptosis in tumor cells. Emerging experimental data also indicate that KD may affect the tumor immune microenvironment by modulating effector and suppressive immune cells and by interacting with immune checkpoint therapy. However, the translation of these data into the clinic is heterogeneous. Early\u2010phase clinical trials and feasibility studies in glioblastoma, breast, colorectal, and pancreatic cancers have shown that KD is feasible in the clinic and that some benefits in metabolic parameters and quality of life are observed, but evidence of anticancer activity remains limited. Importantly, the response to KD in the clinic seems to depend on the formulation and implementation of the dietary intervention, including the use of high\u2010fat KDs versus very\u2010low\u2010calorie ketogenic diets (VLCKDs), as well as the metabolic context in which the intervention is performed, including obesity and insulin resistance. Overall, current data support KD as a biologically plausible and hypothesis\u2010generating immunometabolic strategy that warrants further evaluation in well\u2010designed, controlled clinical trials with careful attention to dietary composition, metabolic phenotype, safety, and patient adherence.<\/jats:p>","DOI":"10.1002\/mnfr.70578","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:01:01Z","timestamp":1787119261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ketogenic Diet: A Metabolic Key to Overcoming Cancer Therapy Resistance"],"prefix":"10.1002","volume":"70","author":[{"given":"Seerwan Hamadameen","family":"Sulaiman","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science College of Health Science Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebaz Anwar","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Health Koya University  Koya, Kurdistan Region \u2013 F.R. Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalamala Ibrahim Salih","family":"Barzani","sequence":"additional","affiliation":[{"name":"Department of Nursing Mergasor Technical Institute Erbil Polytechnic University Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanco Hassan","family":"Jawhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Health Sciences Hawler Medical University  Erbil Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemn A.H.","family":"Barzani","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science College of Health Science Lebanese French University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010023\u201008809\u20103"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/epd2.70093"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.06.026"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708100105"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20100287"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010018\u20101448\u20100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.018"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145207"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.08.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3923"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.08.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20105\u201036"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12225"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.21.11.1097"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319\u20104170.107154"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01765.x"},{"issue":"3","key":"e_1_2_12_19_1","first-page":"387","article-title":"Dietary or Enteral Medium\u2010Chain Triglyceride Usage in a Chinese General Hospital","volume":"24","author":"Li R.","year":"2015","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_12_20_1","doi-asserted-by":"crossref","unstructured":"K. H. K.HoonChul L. H. S. L.HyunSug Y. S. J. Y.SuJeong et\u00a0al. \u201cUse of a modified Atkins diet in intractable childhood epilepsy \u201d (2007):182\u2013186 http:\/\/www.blackwell\u2010synergy.com\/servlet\/useragent?func=showIssues&code=epi.","DOI":"10.1111\/j.1528-1167.2006.00910.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.116"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010019\u201001061\u20102"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.05.007"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801682"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000228999"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051654"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/NT.0b013e31828814eb"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20041"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40170\u2010022\u201000288\u20107"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.76"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2630565"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010025\u201003798\u2010w"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2023.09.010"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14457"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010021\u201001732\u2010y"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01959.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2017.03.027"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111258"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122093"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20107\u20107"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.17.12731"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.155"},{"key":"e_1_2_12_43_1","first-page":"1","volume-title":"Low Carbohydrate Living","author":"Volek J. S.","year":"2011"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12591"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0250"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21499"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115787"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180444"},{"key":"e_1_2_12_49_1","unstructured":"J.Maqbool \u201cExploring the role of gut microbiota and ketogenic diet on glioma growth and tumor microenvironment \u201d (2025) https:\/\/iris.uniroma1.it\/bitstream\/11573\/1733107\/1\/Tesi_dottorato_Maqbool.pdf."},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u20108\u2010122"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129802"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201023\u20102742"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20108\u201054"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010020\u201003417\u20108"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy119"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.06.028"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1645864"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00390"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15192"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2536"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2014"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010\u20100030"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.9712"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010014\u20109495\u20103"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20104\u20105"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036197"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20107075\u20107\u201033"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1650942"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010020\u201001331\u20105"},{"key":"e_1_2_12_71_1","doi-asserted-by":"crossref","unstructured":"U.K\u00e4mmerer R. J.Klement M.S\u00fctterlin andM.Reuss\u2010Borst \u201cLow carb (LCD) and ketogenic (KD) diets increase quality of life physical performance body composition and metabolic health of women with breast cancer better than a standard diet (SD) \u201d (2020) https:\/\/doi.org\/10.21203\/rs.3.rs\u201028430\/v1.","DOI":"10.21203\/rs.3.rs-28430\/v1"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020206"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.14067"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502135"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.e15709"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010021\u201002615\u2010y"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.01.023"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2019.03.007"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152311"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12937\u2010020\u201000596\u2010y"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2022.17.4.812"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233662"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.05.015"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.06.042"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201014\u20102317"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100343\u20104"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00986.2010"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093202"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14190"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.04.001"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.23.18254"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100114"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227166"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14153245"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.05.010"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17061060"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010025\u201001076\u20109"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2025.102217"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2021.1950991"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201006675\u20106"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010021\u201008808\u20102"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510839"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_509_18"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1177\/1973798X251391703"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2382"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758835919853958"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010020\u201004429\u20105"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001007"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1667\/RADE\u201020\u201000150.1"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14668.1"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2021.12.008"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1589584"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.110659"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1445"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2025.2488065"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.01.25328728"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066\u2010022\u201001941\u20102"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102\u2010991"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201019\u20103356"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2762"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201021\u20101059"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1226"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010024\u201003867\u20103"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.004"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz6314"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1344891"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.005"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/immuno3010001"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105067"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102337\u20107"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202702"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c04041"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201021\u20102778"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103969"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107494"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106074.TUMIMM22\u2010A57"},{"key":"e_1_2_12_139_1","first-page":"A1","article-title":"P05. 01 Sensitizing Immunotherapy Refractory Prostate Cancer With Optimized Ketogenic Diet Regimen and Epigenetic Reprogramming","volume":"12","author":"Lu X.","year":"2024","journal-title":"Journal of ImmunoTherapy of Cancer"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.12788\/fp.0399"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.AM2024\u20107597"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1158\/2767\u20109764.CRC\u201022\u20100256"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41231\u2010024\u201000178\u20108"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.70.e111822"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.AM2015\u20101344"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.03.037"},{"key":"e_1_2_12_147_1","volume-title":"Evaluating the Effects of Fasting Conditions in Combination With Temozolomide for the Treatment of Glioblastoma Multiforme","author":"Duffy J.","year":"2020"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1804947"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104500"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16188"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.05.001"},{"issue":"2","key":"e_1_2_12_152_1","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1016\/j.ijrobp.2023.06.1232","article-title":"Promoting the Anti\u2010Tumor Activity of Radiotherapy on Lung Cancer Through a Modified Ketogenic Diet and the AMPK Signaling Pathway","volume":"117","author":"Xiao L.","year":"2023","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.12.005"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102377\u201011\u201010"},{"key":"e_1_2_12_155_1","unstructured":"M.NazarovaandI. F.K H \u201cKetogenic Diet In Treatment of Metabolic Syndrome \u201d (2024) \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0422\u041c\u0410 2024 SPECIAL EDITION Only English \u2032ADVANCES in MEDICAL RESEARCH chrome\u2010extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj https:\/\/repo.tma.uz\/jspui\/bitstream\/1\/773\/1\/12.pdf."},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2005.09503.x"},{"key":"e_1_2_12_157_1","first-page":"14","article-title":"Maximizing the Potential of Ketogenic Dieting as a Potent, Safe, Easy\u2010to\u2010Apply and Cost\u2010Effective Anti\u2010Cancer Therapy","volume":"12","author":"Egba S. I.","year":"2025","journal-title":"Cancer"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4942"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101453"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.01.011"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.002"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102019\u2010234223"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010014\u20101362\u20100"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70578","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:34:56Z","timestamp":1787895296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":162,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/mnfr.70578"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70578","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70578"}}