{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:19:29Z","timestamp":1787897969456,"version":"build-2784847793"},"reference-count":64,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cisplatin\u2010induced acute kidney injury (AKI) is a dose\u2010limiting chemotherapy complication laking effective clinical interventions. This study investigated the protective mechanisms of proanthocyanidins (PACs), a promising food\u2010derived polyphenol, against cisplatin\u2010induced systemic toxicity in C57BL\/6 mice. Multi\u2010omics integration combining 16S rRNA sequencing and renal transcriptomics, was employed to identify microbial\u2010metabolic signaling nodes. Notably, 7\u2010day PAC pretreatment (25 or 50\u00a0mg\/kg\/day) significantly alleviated renal dysfunction, normalized serum creatinine, blood urea nitrogen, reinforced renal antioxidant defenses, and suppressed kidney inflammation. Transcriptomic profiling revealed that cisplatin\u2010induced renal damage was associated with the dysregulation of the cAMP signaling pathway, which was effectively reversed by PACs. Furthermore, 16S rRNA sequencing revealed that PACs restructured the gut microbiota by suppressing the pathogenic taxa (\n                    <jats:italic>Alistipes<\/jats:italic>\n                    and\n                    <jats:italic>CAG_485<\/jats:italic>\n                    ) and enriching beneficial taxa (\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    ). Integrated network analysis further linked these microbial shifts to the stabilization of renal cAMP signaling and redox homeostasis, suggesting a coordinated gut\u2010kidney crosstalk. In conclusion, PACs function as a multifaceted food\u2010derived adjuvant that potentially attenuates cisplatin\u2010induced AKI, providing a molecular framework for gut\u2010targeted nutritional intervention in chemotherapy\u2010induced systemic toxicity.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70582","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:58:26Z","timestamp":1787119106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proanthocyanidins Attenuate Cisplatin\u2010Induced Acute Kidney Injury and are Associated With Reshaping Gut Microbiota and Restoring Redox Homeostasis"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2219-6146","authenticated-orcid":false,"given":"Xianjie","family":"Li","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Healthcare Devices, Institute of Biological 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