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The current review provides a comprehensive overview of the phytochemical constituents and heart\u2010protective therapeutic properties of\n                    <jats:italic>Crataegus orientalis<\/jats:italic>\n                    . Despite numerous reviews on the biological properties of the\n                    <jats:italic>Crataegus<\/jats:italic>\n                    genus.\n                    <jats:italic>C. orientalis<\/jats:italic>\n                    has emerged as a promising therapeutic agent in managing the increasing cardiovascular complications that have followed the COVID\u201019 pandemic. This review highlights the primary cardioprotective biological effects of\n                    <jats:italic>C. orientalis<\/jats:italic>\n                    , including antioxidant, anti\u2010inflammatory, hypolipidemic, antihyperglycemic, antihypertensive, anticoagulant, anti\u2010ischemic, diuretic, and cardiotonic properties, supported by numerous scientific studies in Web of Science, Google Scholar, and PubMed. This updated review provides an overview of the bioactive molecular components of\n                    <jats:italic>C. orientalis<\/jats:italic>\n                    and their cardioprotective mechanisms in cardiac muscle cell biology following the post\u2010COVID\u201019 Pandemic, exploring its potential as an innovative functional food dietary supplement to enhance plant\u2010derived cardioprotective formulations and its possible health benefits. This study presents a significant challenge for analyzing the active constituents of\n                    <jats:italic>C. orientalis<\/jats:italic>\n                    , which require further research, as they are expected to be promising candidates for developing new approaches to prevent and treat various post\u2010pandemic cardiovascular diseases (CVD).\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70590","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:39:43Z","timestamp":1787895583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Review on Cardioprotective Biological Properties of\n                    <i>Crataegus orientalis<\/i>\n                    in Post\u2010COVID\u201019 Pandemic Cardiovascular Disorders"],"prefix":"10.1002","volume":"70","author":[{"given":"Ayman M.","family":"Mousa","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences College of Applied Medical Sciences Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdoon A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry and Pharmacognosy College of Pharmacy Qassim University  Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.43947"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010024\u201000855\u20102"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/f11050564"},{"key":"e_1_2_16_5_1","first-page":"1","article-title":"Oxidative Stress and Antioxidants in Health and Disease","volume":"47","author":"Klran T. 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