{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:18:07Z","timestamp":1787897887217,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Postbiotics, composed of inanimate microorganisms or their components, are gaining attention for managing intestinal discomfort, being safer than probiotics for vulnerable patients. This study investigates the effects of short\u2010term consumption of a heat\u2010stabilized VSL#3 formulation (VSL#3\n                      <jats:sup>\u2212<\/jats:sup>\n                      HS) in a mouse model of dextran sulphate sodium (DSS)\u2010induced colitis. Male C57BL\/6 mice were divided into four groups: (1) Placebo (PLA); (2) VSL#3\u2010HS (1\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      cells\/mouse\/day for 7 days); (3) DSS + PLA (2% DSS in drinking water from days 1\u20137, PLA from days 4\u201310); (4) DSS\u00a0+\u00a0VSL#3\u2010HS (2% DSS from days 1\u20137, VSL#3\u2010HS from days 4\u201310). All mice were euthanized on day 11 for tissue collection. VSL#3\n                      <jats:sup>\u2212<\/jats:sup>\n                      HS rapidly alleviated clinical signs of the disease, including improvements in disease activity index and colon length. This effect was accompanied by a reduction in colonic pro\u2010inflammatory mediators (IL\u20106, TNF\u2010\u03b1, IL\u20101\u03b2) and a partial restoration of occludin gene expression in the intestine. However, no improvement was observed in MPO activity or microscopic tissue damage. The experimental findings demonstrate the efficacy of postbiotics in a murine model of UC and support further investigation into the efficacy of the heat\u2010stabilized VSL#3\u2010HS formulation to assess its potential applicability in human studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70594","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:22:06Z","timestamp":1787296926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effect of a Heat\u2010Stabilized Bacteria Probiotic Preparation (VSL#3\u2010HS) in a Mouse Model of Ulcerative Colitis Induced by Dextran Sulfate Sodium"],"prefix":"10.1002","volume":"70","author":[{"given":"Chiara","family":"Santucci","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Cell Biology Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Torcinaro","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Santa","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology Monterotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Giustiniani","sequence":"additional","affiliation":[{"name":"Department of Pathology Fondazione Policlinico Universitario A. 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