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EPA\u2010acylated astaxanthin (EA), a novel fish oil, has unclear effects on UC. This study constructed a DSS\u2010induced chronic\u2010like relapsing colitis model in mice induced by 2% dextran sulfate sodium (DSS) and primarily concentrated on the changes in gut microbiota and intestinal bile acids (BA) to investigate the anti\u2010UC mechanisms of EA. The results indicated that EA effectively upregulated the expressions of tight junction proteins, ZO\u20101 and Occludin, while restraining the triggering of the NLRP3 inflammasome. Additionally, EA treatment increased the diversity of the gut microbiota and increased the proportion of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    ,\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    , and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , while decreasing the proportion of\n                    <jats:italic>Bacteroidota<\/jats:italic>\n                    ,\n                    <jats:italic>Proteobacteria<\/jats:italic>\n                    , and\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    , which are related to BA metabolism. The metabolomic analysis of BA indicated that EA elevated the concentrations of secondary BA, such as LCA, UDCA, and TUDCA, while decreasing primary BA, such as CA, CDCA, and \u03b2\u2010MCA, thereby activating the intestinal ASBT\/FXR\/TGR5 pathway. In conclusion, EA alleviated DSS\u2010induced colitis, and this protective effect was associated with the modulation of gut microbiota and BA metabolism. The present results laid the foundation for EA as a prospective functional component for UC.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70598","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:08:55Z","timestamp":1791788935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eicosapentaenoic Acid\u2010Acylated Astaxanthin Ameliorates DSS\u2010Induced Chronic\u2010Like Relapsing Colitis Associated With Gut Microbiota and Bile Acid Metabolism"],"prefix":"10.1002","volume":"70","author":[{"given":"Shusen","family":"He","sequence":"first","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolian","family":"Jing","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsen","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao University of Science and Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8733-0843","authenticated-orcid":false,"given":"Hongxia","family":"Che","sequence":"additional","affiliation":[{"name":"College of Biological Engineering Shandong Provincial Key Laboratory of Biochemical Engineering Qingdao 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