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However, the disconnection between bioactive substance extraction and efficacy validation hampers the development of integrated functional interventions. Here, a green and efficient subcritical ethanol\u2010water extraction (SEWE) system was developed to obtain puerarin\u2010enriched extracts (PEE) from\n                    <jats:italic>Pueraria lobata<\/jats:italic>\n                    . By introducing ethanol as a green polarity\u2010modifying co\u2010solvent, the SEWE system enabled polarity\u2010tunable extraction under relatively mild subcritical conditions, thereby balancing extraction efficiency and compound stability. Compared with conventional extraction methods, SEWE significantly enhanced puerarin enrichment and overall extract quality, and the resulting extracts (SEWE\u2010P) further exhibited enhanced bioactivities, including antioxidant, enzyme inhibitory, and anti\u2010inflammatory effects, together with intracellular ROS\u2010scavenging capacity, while maintaining good biocompatibility in vitro. In streptozotocin\u2010induced diabetic mice, oral administration of SEWE\u2010P significantly improved glycemic control, enhanced insulin sensitivity, and promoted pancreatic \u03b2\u2010cell recovery. Mechanistically, SEWE\u2010P activated the PI3K\/AKT signaling pathway to improve glucose metabolism and suppressed NF\u2010\u03baB\u2010mediated inflammation and oxidative stress. Overall, this study establishes an integrated green extraction\u2013function evaluation strategy, providing a scalable approach for the development of multifunctional plant\u2010based antidiabetic interventions.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70603","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:37:52Z","timestamp":1789724272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green and Efficient Extraction of Puerarin\u2010Enriched Extracts From\n                    <i>Pueraria lobata<\/i>\n                    via Subcritical Ethanol\u2010Water for Multi\u2010Target Antidiabetic Effects"],"prefix":"10.1002","volume":"70","author":[{"given":"Xiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering School of Engineering China Pharmaceutical University  Nanjing China"},{"name":"School of Life and Health 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