{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:03:28Z","timestamp":1790665408582,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bovine colostrum and\n                    <jats:italic>Tremella fuciformis<\/jats:italic>\n                    polysaccharide (TEP) exhibit bioactivities when used individually. However, the efficacy of their combined application remains unclear. Therefore, the present study aimed to investigate whether the co\u2010administration of bovine colostrum and TEP exhibits synergistic effects in enhancing antioxidant capacity, immunomodulation, and gut microbiota regulation in mice. The results showed that TEP is composed of mannose, xylose, fucose, glucose, and glucuronic acid. The combined use of medium concentrations of bovine colostrum (125\u00a0mg\/kg) and TEP (50\u00a0mg\/kg) was exhibited serum MDA levels of 8.20 \u00b1 0.54 nmoL\/mL, GSH levels of 80.85 \u00b1 3.12 \u00b5moL\/mL, and IgA levels of 13.46 \u00b1 0.69\u00a0mg\/mL, significantly outperforming the high\u2010dose monotherapies (bovine colostrum 625\u00a0mg\/kg or TEP 250\u00a0mg\/kg). Besides, the combined use of medium concentrations of bovine colostrum and polysaccharide was significantly more effective than high concentrations of either substance alone in elevating serum levels of IgA, IgM, LZM, TNF\u2010\u03b1, IL\u20106, and the gut abundance of\n                    <jats:italic>Bifidobacteriu<\/jats:italic>\n                    m and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    of normal mice. These findings demonstrate that the combined use of bovine colostrum and TEP exhibits synergistic effects, which provide new insights for the formulation and development of dietary supplements and functional foods.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70604","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:44:48Z","timestamp":1790664288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Effects of Bovine Colostrum and\n                    <i>Tremella fuciformis<\/i>\n                    Polysaccharide on Enhancing Antioxidant Capacity, Immunomodulation, and Gut Microbiota Regulation in Mice"],"prefix":"10.1002","volume":"70","author":[{"given":"Yuhao","family":"Huang","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao Shandong Province P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggang","family":"Xie","sequence":"additional","affiliation":[{"name":"Heilongjiang Feihe Dairy Co., Ltd.  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Ren","sequence":"additional","affiliation":[{"name":"Heilongjiang Feihe Dairy Co., Ltd.  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-681X","authenticated-orcid":false,"given":"Zhenxing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Ocean University of China  Qingdao Shandong Province P.R. 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