{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:55:45Z","timestamp":1790582145807,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Postbiotic interventions represent a promising strategy to modulate gut health, but clinical evidence in older adults is limited. This study aimed to evaluate the effects of a postbiotic supplement consisting of inactivated bacterial cells on bowel function, systemic inflammation, and gut microbiota composition in institutionalized older adults. In this randomized, double\u2010blind intervention study, 48 older adults received either postbiotic or placebo for 8 weeks. Daily assessment of gastrointestinal manifestations, bowel movements, and laxative use were collected, alongside pre\u2010 and post\u2010intervention hematological and clinical biochemical assessments. Postbiotic supplementation improved bowel regularity, reduced diarrheal episodes, and decreased laxative reliance, effects that paralleled reductions in systemic inflammatory markers and improvements in red blood cell parameters. These clinical and hematological changes were accompanied by a more favorable gut microbiota profile, characterized by an increase in bacterial groups associated with anti\u2010inflammatory effects in the postbiotic group and of taxa linked to dysbiosis in the placebo group. Our findings suggest that postbiotic supplementation in institutionalized older adults promotes beneficial shifts in gut microbiota, which are associated with reduced systemic low\u2010grade inflammation and consequent improvements in bowel function and inflammation\u2010related anemia, indicating an integrated microbiota\u2010mediated mechanism supporting gut and systemic health.<\/jats:p>","DOI":"10.1002\/mnfr.70610","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:35:17Z","timestamp":1789724117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postbiotic Intervention Improves Bowel Function and Promotes Systemic Health in Institutionalized Older Adults"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-3756","authenticated-orcid":false,"given":"Mar\u00eda","family":"Bravo","sequence":"first","affiliation":[{"name":"INGULADOS SL Miguel Servet 11\u201013 C\u00e1ceres, Extremadura Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth D.","family":"Herrera D\u00edaz","sequence":"additional","affiliation":[{"name":"Servicio Extreme\u00f1o de Salud, C.R. El Cuartillo  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4449-2025","authenticated-orcid":false,"given":"Carmen","family":"Bravo Santillana","sequence":"additional","affiliation":[{"name":"Servicio Extreme\u00f1o de Promoci\u00f3n de La Autonom\u00eda Personal y Atenci\u00f3n a la Dependencia, C.R. El Cuartillo  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mart\u00edn Terroso","sequence":"additional","affiliation":[{"name":"Servicio Extreme\u00f1o de Promoci\u00f3n de La Autonom\u00eda Personal y Atenci\u00f3n a la Dependencia, C.R. El Cuartillo  C\u00e1ceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7788-481X","authenticated-orcid":false,"given":"Irene","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"INGULADOS SL Miguel Servet 11\u201013 C\u00e1ceres, Extremadura Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Cerrato","sequence":"additional","affiliation":[{"name":"INGULADOS SL Miguel Servet 11\u201013 C\u00e1ceres, Extremadura Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101323"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3RI0620\u2010405RR"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010020\u201000213\u2010w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i35.6815"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105281"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010023\u201004438\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508\u2010023\u201002156\u2010w"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108944"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13072049"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-022-1842-4"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000440\u20106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2018.03.009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194673"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14113673"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.13444"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17132187"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15081190"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00289-7"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","unstructured":"World Medical Association World Medical Association Declaration of Helsinki \" JAMA 2013 310 2191 https:\/\/doi.org\/10.1001\/jama.2013.281053.","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13030200"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01385\u201021"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12259"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010019\u20100264\u20101"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8081177"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082189"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-022-01189-0"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002028"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010024\u201000469\u20106"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132559"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001219\u20109"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010023\u201003132\u20100"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.06.011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2019.03.005"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.2010.00760.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042422"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201003275\u20101"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01285"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-025-10832-8"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105441"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.634897"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010016\u20107343\u20109"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010020\u201001125\u20102"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i33.5555"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:06:50Z","timestamp":1790579210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":43,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mnfr.70610"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70610","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70610"}}