{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:55:48Z","timestamp":1790582148615,"version":"4.1.0"},"reference-count":108,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastrodin (GAS), a natural polyphenolic compound derived primarily from\n                    <jats:italic>Gastrodia elata<\/jats:italic>\n                    , exhibited a wide spectrum of pharmacological activities, with growing evidence supporting its anticancer potential. This review summarized preclinical findings on the anticancer effects of GAS across multiple cancer types, including brain, breast, colorectal, liver, oral, and skin cancers. The literature was systematically collected from major databases such as PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies published from 2013 onward. Evidence indicates that GAS exerted anticancer effects via multiple cellular and molecular mechanisms, including apoptosis, ferroptosis, cell cycle arrest, inhibition of glycolysis, suppression of oncogenic signaling pathways (e.g., NF\u2010\u03baB, PI3K\/Akt), immune modulation, and attenuation of inflammation and oxidative stress. Preclinical in vitro and in vivo studies demonstrated significant tumor growth suppression and the ability of GAS to overcome drug resistance. Pharmacokinetic studies revealed favorable drug\u2010like properties, while toxicological evaluations highlighted its high safety margin with minimal adverse effects. Despite promising findings, the lack of clinical trials and standardized protocols remained a major limitation. Collectively, GAS represents a promising natural product candidate with potential as an adjunct or alternative anticancer therapy, warranting further translational and clinical investigation.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70613","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:50:35Z","timestamp":1790578235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrodin as a Multitarget Anticancer Agent: Mechanisms, Pharmacokinetics, Toxicology, and Clinical Evidence"],"prefix":"10.1002","volume":"70","author":[{"given":"Akayed","family":"Hasan","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Science Duquesne University  Pittsburgh USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imam Hossen","family":"Rakib","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medicine Program Batterjee Medical College  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abul Bashar Ripon","family":"Khalipha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Y.","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Central Labs King Khalid University  Abha Saudi Arabia"},{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Jouf University  Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Asaduzzaman","family":"Jony","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noshin Tasnim","family":"Yana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakib","family":"Hossan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituparna Biswas","family":"Suma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University  Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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