{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:04:53Z","timestamp":1790665493999,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Flavan\u20103\u2010ols are among the most widely consumed flavonoids and have been implicated in the prevention of cardiometabolic diseases. Increasing evidence indicates that phenolic metabolites produced by the gut microbiota from flavan\u20103\u2010ols contribute significantly to these effects. While some bacterial species can metabolize flavan\u20103\u2010ol monomers, no isolates with activity on oligomers, i.e., procyanidins, have been reported. Since the gut microbiota is known to hydrolyze procyanidins, our aim was to identify bacteria capable of degrading them and to characterize their resulting metabolites. Through culturomic, genomic, and metabolomic approaches, we isolated novel strains of\n                      <jats:italic>Eggerthella lenta<\/jats:italic>\n                      and\n                      <jats:italic>Flavonifractor plautii<\/jats:italic>\n                      that metabolize flavan\u20103\u2010ol monomers. Their activity was subsequently tested on B\u2010type (DP 2 to 4) and A\u2010type (DP 2) procyanidins. Only\n                      <jats:italic>E. lenta<\/jats:italic>\n                      was able to convert procyanidins, whereas\n                      <jats:italic>F. plautii<\/jats:italic>\n                      , either alone or in co\u2010culture with\n                      <jats:italic>E. lenta<\/jats:italic>\n                      , showed no detectable activity. The reaction catalyzed by\n                      <jats:italic>E. lenta<\/jats:italic>\n                      corresponded to C\u2010ring opening of the terminal unit of the oligomers. This work provides the first demonstration of procyanidin metabolism by a human gut bacterium. The presence and activity of\n                      <jats:italic>E. lenta<\/jats:italic>\n                      in the gut may therefore be a key determinant of the health benefits associated with flavan\u20103\u2010ol\u2013rich diets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70615","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:53:28Z","timestamp":1790664808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolization of Flavan\u20103\u2010ol Oligomers by\n                    <i>Eggerthella lenta<\/i>\n                    , a Human Gut Bacterium"],"prefix":"10.1002","volume":"70","author":[{"given":"Ruben","family":"Halifa","sequence":"first","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dufour","sequence":"additional","affiliation":[{"name":"UMR408 SQPOV INRAE, Avignon Universit\u00e9  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Cornu","sequence":"additional","affiliation":[{"name":"UMR1213 Herbivores INRAE, VetAgroSup\u2010Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruiz","sequence":"additional","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"},{"name":"BioinfOmics, GenoToul Bioinformatics Facility Universit\u00e9 de Toulouse, INRAE Castanet\u2010Tolosan France"},{"name":"UMR 875 MIAT Universit\u00e9 de Toulouse, INRAE Castanet\u2010Tolosan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Danon","sequence":"additional","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ginies","sequence":"additional","affiliation":[{"name":"UMR408 SQPOV INRAE, Avignon Universit\u00e9  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dubourdeaux","sequence":"additional","affiliation":[{"name":"HerbalT  Saint\u2010Bonnet\u2010de\u2010Rochefort France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Comtet\u2010Marre","sequence":"additional","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Peyret","sequence":"additional","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Le Bourvellec","sequence":"additional","affiliation":[{"name":"UMR408 SQPOV INRAE, Avignon Universit\u00e9  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Mosoni","sequence":"additional","affiliation":[{"name":"UMR 454 MEDIS Universit\u00e9 Clermont Auvergne, INRAE  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy229"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz178"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16152471"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.3390\/nu11061355","article-title":"Systematic Review on Polyphenol Intake and Health Outcomes: Is There Sufficient Evidence to Define a Health\u2010Promoting Polyphenol\u2010Rich Dietary Pattern?","volume":"11","author":"Del Bo' C.","year":"2019","journal-title":"Nutrients"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jn\/134.3.613","article-title":"Concentrations of Proanthocyanidins in Common Foods and Estimations of Normal Consumption","volume":"134","author":"Gu L. 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