{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:05:04Z","timestamp":1790665504849,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose of Review<\/jats:title>\n                    <jats:p>Hyperglycemia and altered carbohydrate metabolism may promote pancreatic cancer cell survival and proliferation. This narrative review critically evaluates epidemiological evidence on whether sugar\u2010sweetened beverage (SSB) consumption is associated with pancreatic cancer risk and examines potential biological mechanisms involving glucose and fructose metabolism, oncogenic KRAS signaling, and metabolic reprogramming. Recent Findings: Earlier pooled analyses and a 2019 meta\u2010analysis found no significant overall association between SSB consumption and pancreatic cancer risk. However, three subsequent studies, including a large prospective cohort from Taiwan and case\u2010control studies from the United States and Jordan, reported positive associations in selected high\u2010consumption groups. Differences in beverage definitions, dietary assessment methods, residual confounding, and study populations complicate comparisons. Mechanistic studies provide biological plausibility, suggesting that glucose and fructose metabolism and KRAS\u2010driven metabolic reprogramming may enhance glycolysis, anabolic metabolism, nutrient acquisition, and cancer cell survival. Summary: Evidence linking SSB consumption to pancreatic cancer remains inconsistent and insufficient to establish causality. Future research should standardize beverage definitions, distinguish SSBs from artificially sweetened beverages and fruit juices, use repeated dietary assessments, control metabolic and lifestyle confounders, include diverse populations, and integrate epidemiological data with metabolic and molecular biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70617","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:45:21Z","timestamp":1790664321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sweetened Beverages and Pancreatic Cancer: Insights From Recent Epidemiological Data and Oncogenic Mechanisms"],"prefix":"10.1002","volume":"70","author":[{"given":"Ha Thi Thao","family":"Mai","sequence":"first","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufar","family":"Mirzaeva","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Tung","family":"Dac","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Tin","family":"Nghia","sequence":"additional","affiliation":[{"name":"Can Tho University of Medicine and Pharmacy  Can Tho Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Anh Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy  Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Luis","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i27.4298"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010024\u201012835\u20100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201073525\u2010y"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i32.4698"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27462"},{"issue":"4","key":"e_1_2_13_7_1","article-title":"Global Cancer Statistics 2024: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 34 Cancers in 186 Countries","volume":"76","author":"Sung H.","year":"2026","journal-title":"CA: A Cancer Journal for 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