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Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death. These effects may occur directly or through the release of adsorbed pollutants and plastic additives. Resveratrol (3,5,4\u2032\u2010trihydroxy\u2010trans\u2010stilbene; RV), a natural polyphenol found in grapes, berries, and peanuts, has attracted interest as a potential protective agent because of its antioxidant and anti\u2010inflammatory properties. Its proposed protective effects against MP\/NP toxicity involve modulation of key cellular signaling pathways, particularly nuclear factor erythroid 2\u2010related factor 2 (Nrf2) and nuclear factor\u2010kappa B (NF\u2010\u03baB). RV may activate Nrf2 by disrupting its interaction with Kelch\u2010like ECH\u2010associated protein 1 (Keap1), thereby enhancing antioxidant defenses, including superoxide dismutase, catalase, and glutathione peroxidase, and reducing reactive oxygen species\u2010mediated damage to lipids, proteins, and DNA. Concurrently, RV may suppress NF\u2010\u03baB\u2010mediated inflammatory responses. However, current evidence is limited to a small number of preclinical studies, with no human studies available. These mechanisms remain largely hypothetical and require validation using standardized MP\/NP exposure models.<\/jats:p>","DOI":"10.1002\/mnfr.70623","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:33:17Z","timestamp":1791441197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol in Microplastic\u2010 and Nanoplastic\u2010Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions"],"prefix":"10.1002","volume":"70","author":[{"given":"Samaneh","family":"Sepahi","sequence":"first","affiliation":[{"name":"Food and Beverages Safety Research Center Urmia University of Medical Sciences  Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibeh","family":"Mashayekhi\u2010Sardoo","sequence":"additional","affiliation":[{"name":"Bio Environmental Health Hazards Research Center Jiroft University of Medical Sciences  Jiroft 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