{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:57Z","timestamp":1792395897978,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The so\u2011called demographic transition has increased the prevalence of chronic diseases in adults over 65, accompanied by a rise in anxiety and depression. This study aimed at investigating the effect of cocoa flavanols and red berries (RB) anthocyanins consumption on depression and anxiety, focusing on the potential of the urinary metabolomic profile in the search for early biomarkers of intake and effect. A randomized, double\u2010blind, parallel\u2010group, 12\u2010week intervention involving 59 healthy volunteers was conducted. The three dietary groups consumed either 5\u00a0g\/day of RB (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020); 2.5\u00a0g\/day of polyphenol\u2010rich cocoa powder (C) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020) or 7.5\u00a0g\/day of a combination of cocoa and red berries (RB+C) (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a019). The Beck Depression Inventory\u2010II (BDI\u2010II) and State\u2010Trait Anxiety Inventory (STAI) were used for emotional assessments. Targeted and untargeted metabolomic analyses were conducted on urine samples. Regular intake of RB significantly reduced state anxiety compared with C. 7\u2010Methylxanthine and 3\u2010methylxanthine confirmed cocoa intake. L\u2010tryptophan, represents an essential metabolic precursor in serotonin biosynthesis. Among evaluated metabolites,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010cresol glucuronide,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010methylhippuric acid, and epicatechin sulfate emerged as key candidates associated with emotional outcomes. These findings support a potential role of dietary polyphenols in modulating the gut\u2013brain axis in an aging population.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70624","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:33:19Z","timestamp":1791441199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenol\u2010Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3128-4090","authenticated-orcid":false,"given":"Mar\u00eda Luc\u00eda","family":"G\u00f3mez Nieto","sequence":"first","affiliation":[{"name":"Departamento de Metabolismo y Nutrici\u00f3n Instituto de Ciencia y Tecnolog\u00eda De los Alimentos y Nutrici\u00f3n (ICTAN\u2010CSIC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-4528","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Puertas\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Universidad Internacional de la Rioja (UNIR)  Logro\u00f1o, La Rioja Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3136-833X","authenticated-orcid":false,"given":"Susana","family":"Chamorro","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-9361","authenticated-orcid":false,"given":"Antonio","family":"M\u00e9ndez\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda Hospital 12 de Octubre  Madrid 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Alimentos y Nutrici\u00f3n (ICTAN\u2010CSIC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"United Nations Department of Economic and Social Affairs World Population Prospects 2024: Summary of Results United Nations New York(2024)."},{"key":"e_1_2_10_3_1","unstructured":"European Commission Directorate\u2010General for Economic and Financial Affairs The 2024 Ageing Report: Economic and Budgetary Projections for the EU Member States (2022\u20132070) Institutional Paper 279 European Union Brussels(2024)."},{"key":"e_1_2_10_4_1","unstructured":"Instituto Nacional de Estad\u00edstica Proyecciones de Poblaci\u00f3n 2024\u20132074 Instituto Nacional de Estad\u00edstica Madrid(2024)."},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization UN Decade of Healthy Ageing: Plan of Action 2021\u20132030 World Health Organization 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