{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:57Z","timestamp":1792395897961,"version":"4.4.0"},"reference-count":162,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Grapes (\n                    <jats:italic>Vitis vinifera<\/jats:italic>\n                    L.) are abundant in polyphenols, flavonoids, and other bioactive constituents. They exhibit a wide range of health\u2010promoting properties, including antioxidant, anti\u2010inflammatory, anticancer, cardioprotective, antidiabetic, and skin anti\u2010aging effects. We review and summarize the phytopharmacological and functional effects of grape\u2010derived compounds. This review includes in vitro, in vivo, and clinical studies. The search combined the terms \u201c\n                    <jats:italic>V. vinifera<\/jats:italic>\n                    \u201d OR \u201cgrape\u201d with keywords related to traditional uses, phytochemistry, and pharmacological activities. Peer\u2010reviewed English\u2010language studies published between 2000 and 2025 reporting ethnobotanical uses, phytochemical composition, or pharmacological effects were included. The findings were synthesized qualitatively. This review showed that grape seed and red grape extracts inhibited the growth of MCF\u20107 and MDA\u2010MB\u2010231 breast cancer cells. Leaf and seed extracts reduced blood glucose in diabetic models, with antioxidant activity IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 35\u201341\u00a0\u00b5g\/mL. Biogenic carbon quantum dots derived from\n                    <jats:italic>V. vinifera<\/jats:italic>\n                    enhanced glucose uptake and inhibited\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010amylase. In hypertensive rats, systolic blood pressure decreased from greater than 200\u00a0mmHg to less than 150\u00a0mmHg. Resveratrol\u2010enriched grape seed oil improved adipose tissue function, enhanced glucose tolerance, and reduced inflammatory markers. Future research should prioritize standardized extracts, optimized dosing strategies, and robust clinical trials to validate their translational potential.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70626","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:17:26Z","timestamp":1791789446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytopharmacological and Functional Insights Into the Bioactive Compounds of Grape (\n                    <i>Vitis vinifera<\/i>\n                    L.): An Integrated Review of In Vitro, In Vivo, and Clinical Studies"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-9601","authenticated-orcid":false,"given":"Gudisa","family":"Bereda","sequence":"first","affiliation":[{"name":"Department of Pharmacy Marie Stopes International Ethiopia (MSIE)  Ambo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-5879","authenticated-orcid":false,"given":"Javed","family":"Ahamad","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma Safeen","family":"Awla","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.52568\/001432\/JCSP\/46.02.2024"},{"key":"e_1_2_23_3_1","first-page":"145","article-title":"Kurdistan Region: A Country Profile","volume":"9","author":"Kirmanj S.","year":"2013","journal-title":"Journal of International Students"},{"issue":"3","key":"e_1_2_23_4_1","first-page":"291","article-title":"Phytochemistry and Ethnopharmacology of Some Medicinal Plants Used in the Kurdistan Region of Iraq","volume":"11","author":"Amin H. 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