{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:44:52Z","timestamp":1792395892777,"version":"4.4.0"},"reference-count":90,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oxylipins are bioactive lipid mediators derived from polyunsaturated fatty acids that regulate the initiation and resolution of inflammation across the body. Dysregulated oxylipin signaling is implicated in numerous chronic diseases, yet dietary strategies capable of modulating these pathways remain poorly defined. Flavonoids, a diverse class of plant\u2010derived polyphenols, are widely consumed and exhibit anti\u2010inflammatory properties, but their influence on oxylipin metabolism as an integrated network has not been comprehensively evaluated. This narrative review synthesizes current evidence describing how flavonoids and flavonoid\u2010rich foods interact with oxylipin biosynthesis through multiple mechanisms, including modulation of phospholipase activity, remodeling of upstream fatty acid pools, and direct modulation of cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 enzymes. Evidence from in vitro systems, animal models, and emerging human trials suggests that flavonoids can alter oxylipin profiles under conditions of basal, metabolic, inflammatory, and exercise\u2010induced stress, with some studies indicating shifts away from pro\u2010inflammatory species and toward pro\u2010resolving mediator intermediates. However, the literature remains fragmented and heavily weighted toward supraphysiological dosing and limited mediator panels, with minimal assessment of tissue\u2010specific effects or flavonoid metabolites. We highlight critical gaps and propose priorities for future research, emphasizing the need for physiologically relevant flavonoid interventions, comprehensive lipidomics, flavonoid\u2010metabolite profiling, and systems\u2010level integration.<\/jats:p>","DOI":"10.1002\/mnfr.70630","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:25:08Z","timestamp":1792394708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids as Modulators of Lipid Mediator Signaling: A Narrative Review on Mechanisms, Current Evidence, and Gaps in the Literature"],"prefix":"10.1002","volume":"70","author":[{"given":"Joseph","family":"Arballo","sequence":"first","affiliation":[{"name":"Food, Bioprocessing and Nutrition Sciences North Carolina State University Plants <i>for<\/i> Human Health Institute  Kannapolis North Carolina United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Lila","sequence":"additional","affiliation":[{"name":"Food, Bioprocessing and Nutrition Sciences North Carolina State University Plants <i>for<\/i> Human Health Institute  Kannapolis North Carolina United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.04.049"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.007732"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200085w"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900004\u2010JLR200"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121238"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.24"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090826"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010019\u201009629\u20109"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u201000114\u2010z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2022.03.011"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20108741(87)90101\u20102"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2018.1454480"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28083599"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28134982"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.727"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010017\u20101445\u20108"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010137"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105\u2010024\u201001046\u20107"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2014.978080"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111489"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060921"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113951"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201039269\u20101"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c04690"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010014\u20109995\u2010x"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2020.25.2.119"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1443"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168847"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u2010511X\u201010\u201036"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956688"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf025716n"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.9.1495"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517000241"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.09.005"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440\u20106047.2002.00305.x"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010015\u20100139\u20108"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010014\u20100540\u20100"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027306118026"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00914195"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010009\u20100268\u2010z"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0326"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20102952(96)00773\u20103"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.12.004"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.09.028"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.10.002"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201035161\u20100"},{"key":"e_1_2_13_51_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.plefa.2009.10.006","article-title":"Myricetin and Quercetin Are Naturally Occurring co\u2010Substrates of Cyclooxygenases in Vivo","volume":"82","author":"Bai H.\u2010W.","year":"2010","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"key":"e_1_2_13_52_1","first-page":"206","article-title":"Inhibition of Sheep Platelet Arachidonate Metabolism by Flavonoids From Spanish and Indian Medicinal Herbs","volume":"45","author":"Ferr\u00e1ndiz M. L.","year":"1990","journal-title":"Die Pharmazie"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1988.tb05173.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(91)90501\u2010U"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114825"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.01.019"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010013\u20100946\u2010z"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028250"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010960838"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1988.tb05250.x"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512006071"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b04501"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114332"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00121"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.05.002"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010024\u201001947\u20109"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.07.020"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac901282n"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adw1245"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2024.101276"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100621"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9AN01880H"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.12.030"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.10.003"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.05.012"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D089516"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120000991"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25020349"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.11.012"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arres.2026.100177"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270646"},{"key":"e_1_2_13_82_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/metabo10060264","article-title":"Oxylipin Response to Acute and Chronic Exercise: A Systematic Review","volume":"10","author":"\u00c9 S.","year":"2020","journal-title":"Metabolites"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9904509"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.838782"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2026.101133"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306\u2010007\u20100081\u20103"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9030043"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/load013"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzaa031"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2013.12.008"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.2.248"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mnfr.70630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.70630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:25:10Z","timestamp":1792394710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.70630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":90,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mnfr.70630"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.70630","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70630"}}