{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:50:05Z","timestamp":1778500205843,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01EB020665"],"award-info":[{"award-number":["1R01EB020665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS\u20101418737"],"award-info":[{"award-number":["DMS\u20101418737"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Purpose<\/jats:title>To provide a fast computational method, based on the proximal graph solver (POGS<\/jats:styled-content>) \u2013 A convex optimization solver using the alternating direction method of multipliers (ADMM<\/jats:styled-content>), for calculating an optimal treatment plan in rotating shield brachytherapy (RSBT<\/jats:styled-content>).RSBT<\/jats:styled-content>treatment planning has more degrees of freedom than conventional high\u2010dose\u2010rate brachytherapy due to the addition of emission direction, and this necessitates a fast optimization technique to enable clinical usage.<\/jats:p><\/jats:sec>Methods<\/jats:title>The multi\u2010helixRSBT<\/jats:styled-content>(H\u2010RSBT<\/jats:styled-content>) delivery technique was investigated for five representative cervical cancer patients. Treatment plans were generated for all patients using thePOGS<\/jats:styled-content>method and the commercially available solverIBM ILOG CPLEX<\/jats:styled-content>. The rectum, bladder, sigmoid colon, high\u2010risk clinical target volume (HR<\/jats:styled-content>\u2010CTV<\/jats:styled-content>), andHR<\/jats:styled-content>\u2010CTV<\/jats:styled-content>boundary were the structures included in our optimization, which applied an asymmetric dose\u2010volume optimization with smoothness control. Dose calculation resolution was 1 \u00d7 1 \u00d7 3 mm3<\/jats:sup>for all cases. The H\u2010RSBT<\/jats:styled-content>applicator had 6 helices, with 33.3 mm of translation along the applicator per helical rotation and 1.7 mm spacing between dwell positions, yielding 17.5\u00b0 emission angle spacing per 5 mm along the applicator.<\/jats:p><\/jats:sec>Results<\/jats:title>For each patient,HR<\/jats:styled-content>\u2010CTV<\/jats:styled-content>D<\/jats:italic>90<\/jats:sub>,HR<\/jats:styled-content>\u2010CTV<\/jats:styled-content>D<\/jats:italic>100<\/jats:sub>, rectumD2cc<\/jats:sub><\/jats:italic>, sigmoidD2cc<\/jats:sub><\/jats:italic>, and bladderD2cc<\/jats:sub><\/jats:italic>matched within 1% forCPLEX<\/jats:styled-content>andPOGS<\/jats:styled-content>methods. Also, similarEQD<\/jats:styled-content>2 values betweenCPLEX<\/jats:styled-content>andPOGS<\/jats:styled-content>methods were obtained.POGS<\/jats:styled-content>was around 18 times faster thanCPLEX<\/jats:styled-content>. For all patients, total optimization times were 32.1\u201365.4 s forCPLEX<\/jats:styled-content>and 2.1\u20133.9 s forPOGS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>POGS<\/jats:styled-content>reduced treatment plan optimization time approximately 18 times forRSBT<\/jats:styled-content>with similarHR<\/jats:styled-content>\u2010CTV<\/jats:styled-content>D<\/jats:italic>90<\/jats:sub>, organ at risk (OAR<\/jats:styled-content>)D2cc<\/jats:sub><\/jats:italic>values, andEQD<\/jats:styled-content>2 values compared toCPLEX<\/jats:styled-content>, which is significant progress toward clinical translation ofRSBT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.12486","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T08:42:43Z","timestamp":1501058563000},"page":"5384-5392","source":"Crossref","is-referenced-by-count":10,"title":["Fast dose optimization for rotating shield 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