{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:03:48Z","timestamp":1761541428015},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the dose calculation accuracy in water medium of the Advanced Collapsed cone Engine (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) for three sizes of <jats:styled-content style=\"fixed-case\">COMS<\/jats:styled-content> eye plaques loaded with low\u2010energy I\u2010125 seeds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A model of the Oncura 6711 I\u2010125 seed was created for use with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> in Oncentra<jats:sup>\u00ae<\/jats:sup> Brachy (OcB) using primary\u2010scatter separated (<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>) point dose kernel and Task Group (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) 43 datasets. <jats:styled-content style=\"fixed-case\">COMS<\/jats:styled-content> eye plaque models of diameters 12, 16, and 20\u00a0mm were introduced into the OcB applicator library based on 3D <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> drawings of the plaques and Silastic inserts. To perform <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\u2010186 level 1 commissioning, treatment plans were created in OcB for a single source in water and for each <jats:styled-content style=\"fixed-case\">COMS<\/jats:styled-content> plaque in water for two scenarios: with only one centrally loaded seed, or with all seed positions loaded. <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> dose calculations were performed in high accuracy mode with a 0.5\u00a0\u00d7\u00a00.5\u00a0\u00d7\u00a00.5\u00a0mm<jats:sup>3<\/jats:sup> calculation grid. The resulting dose data were evaluated against Monte Carlo (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) calculated doses obtained with <jats:styled-content style=\"fixed-case\">MCNP<\/jats:styled-content>6, using both local and global percent differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> doses around the source for the single seed in water agreed with <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> doses on average within &lt;\u00a05% inside a 6\u00a0\u00d7\u00a06\u00a0\u00d7\u00a06\u00a0cm<jats:sup>3<\/jats:sup> region, and within &lt;\u00a01.5% inside a 2\u00a0\u00d7\u00a02\u00a0\u00d7\u00a02\u00a0cm<jats:sup>3<\/jats:sup> region. The <jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content> data were generated at a higher resolution within 2\u00a0cm from the source, resulting in this improved agreement closer to the source due to fewer approximations in the <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> dose calculation. Average differences in both investigated plaque loading patterns in front of the plaques and on the plaque central axes were \u2264\u00a02.5%, though larger differences (up to 12%) were found near the plaque lip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, good agreement was found between <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> dose calculations for a single I\u2010125 seed and in front of the <jats:styled-content style=\"fixed-case\">COMS<\/jats:styled-content> plaques in water. More complex scenarios need to be investigated to determine how well <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> handles heterogeneous patient materials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.12776","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T14:08:54Z","timestamp":1517407734000},"page":"1276-1286","source":"Crossref","is-referenced-by-count":6,"title":["Initial evaluation of Advanced Collapsed cone Engine dose calculations in water medium for I\u2010125 seeds and <scp>COMS<\/scp> eye plaques"],"prefix":"10.1002","volume":"45","author":[{"given":"Hali","family":"Morrison","sequence":"first","affiliation":[{"name":"Department of Medical Physics Cross Cancer Institute Edmonton Alberta Canada"},{"name":"Department of Oncology University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Cross Cancer Institute Edmonton Alberta Canada"},{"name":"Department of Oncology University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Larocque","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Cross Cancer Institute Edmonton Alberta Canada"},{"name":"Department of Oncology University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"van Veelen","sequence":"additional","affiliation":[{"name":"Elekta Brachytherapy Veenendaal The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yury","family":"Niatsetski","sequence":"additional","affiliation":[{"name":"Elekta Brachytherapy Veenendaal The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezekiel","family":"Weis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Alberta Edmonton Alberta Canada"},{"name":"Department of Surgery University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron S.","family":"Sloboda","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Cross Cancer Institute Edmonton Alberta Canada"},{"name":"Department of Oncology University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(93)90052-F"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/archopht.119.7.969","article-title":"The COMS randomized trial of Iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. 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