{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:53:14Z","timestamp":1771919594808,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Talbot\u2013Lau x\u2010ray interferometry provides information about the scattering and refractive properties of an object \u2014 in addition to the object's attenuation features. Until recently, this method was ineligible for imaging human\u2010sized objects as it is challenging to adapt Talbot\u2013Lau interferometers (<jats:styled-content style=\"fixed-case\">TLI<\/jats:styled-content>s) to the relevant x\u2010ray energy ranges. In this work, we present a preclinical Talbot\u2013Lau prototype capable of imaging human\u2010sized objects with proper image quality at clinically acceptable dose levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">TLI<\/jats:styled-content> is designed to match a setup of clinical relevance as closely as possible. The system provides a scan range of 120\u00a0\u00d7\u00a030\u00a0cm<jats:sup>2<\/jats:sup> by using a scanning beam geometry. Its ultimate load is 100\u00a0kg. High aspect ratios and fine grid periods of the gratings ensure a reasonable setup length and clinically relevant image quality. The system is installed in a university hospital and is, therefore, exposed to the external influences of a clinical environment.<\/jats:p><jats:p>To demonstrate the system's capabilities, a full\u2010body scan of a euthanized pig was performed. In addition, freshly excised porcine lungs with an extrinsically provoked pneumothorax were mounted into a human thorax phantom and examined with the prototype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both examination sequences resulted in clinically relevant image quality \u2014 even in the case of a skin entrance air kerma of only 0.3\u00a0mGy which is in the range of human thoracic imaging. The presented case of a pneumothorax and a reader study showed that the prototype's dark\u2010field images provide added value for pulmonary diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that a dedicated design of a Talbot\u2013Lau interferometer can be applied to medical imaging by constructing a preclinical Talbot\u2013Lau prototype. We experienced that the system is feasible for imaging human\u2010sized objects and the phase\u2010stepping approach is suitable for clinical practice.<\/jats:p><jats:p>Hence, we conclude that Talbot\u2013Lau x\u2010ray imaging has potential for clinical use and enhances the diagnostic power of medical x\u2010ray imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.12889","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T02:36:45Z","timestamp":1522118205000},"page":"2565-2571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A preclinical Talbot\u2013Lau prototype for x\u2010ray dark\u2010field imaging of human\u2010sized objects"],"prefix":"10.1002","volume":"45","author":[{"given":"C.","family":"Hauke","sequence":"first","affiliation":[{"name":"Siemens Healthcare GmbH 91301 Forchheim Germany"},{"name":"Erlangen Centre for Astroparticle Physics FAU Erlangen\u2010Nuremberg 91058 Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bartl","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH 91301 Forchheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Leghissa","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH 91301 Forchheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ritschl","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH 91301 Forchheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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