{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:00:17Z","timestamp":1783774817966,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010EB003268"],"award-info":[{"award-number":["R01\u2010EB003268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To correlate the accumulated thermal dose (ATD) with lesion size in magnetic resonance (MR)\u2010guided focused ultrasound (MRgFUS) thalamotomy to help guide future clinical treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010six patients with medication\u2010refractory essential tremor were treated using a commercial MRgFUS brain system (ExAblate 4000, InSightec) in a 3T MR scanner (MR750, GE Healthcare). Intraoperative MR\u2010thermometry was performed to measure the induced temperature and thermal dose distributions (thermal coefficient\u00a0=\u00a0\u22120.00909\u00a0ppm\/\u00b0C). The ATD was calculated over multiple sonications with appropriate corrections for spatial\u2010shifting artifacts. The ATD profile sizes obtained for dose values of 17, 40, 100, 200, and 240 cumulative equivalent minutes at 43\u00b0C (CEM) were correlated with the corresponding lesion sizes measured via axial T1\u2010 and T2\u2010weighted MR images acquired 1\u00a0day post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 232 included sonications, 83 required corrections for off\u2010resonance\u2010induced spatial\u2010shifting artifacts (correction range\u00a0=\u00a0[1.1,2.2]\u00a0mm). The mean lesion sizes measured on T2\u2010weighted MR images (6.2\u00a0\u00b1\u00a01.3\u00a0mm, mean\u00a0\u00b1\u00a0SD) were 15% larger than those measured on corresponding T1\u2010weighted MR images (5.3\u00a0\u00b1\u00a01.2\u00a0mm, mean\u00a0\u00b1\u00a0SD). The ATD values that provided the best correlations with the measured lesion sizes on T2\u2010 and T1\u2010weighted MR images were 100 and 200 CEM, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ATD was correlated with lesion size measured 1\u00a0day following MRgFUS thalamotomy for essential tremor. These data provide useful information for predicting brain lesion size and determining treatment endpoints in future clinical MRgFUS procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.13126","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T07:20:26Z","timestamp":1533972026000},"page":"4704-4710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Predicting lesion size by accumulated thermal dose in MR\u2010guided focused ultrasound for essential tremor"],"prefix":"10.1002","volume":"45","author":[{"given":"Yuexi","family":"Huang","sequence":"first","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute 2075 Bayview Avenue Toronto ON M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Lipsman","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre 2075 Bayview Avenue Toronto ON M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Sunnybrook Health Sciences Centre 2075 Bayview Avenue Toronto ON M4N 3M5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhor","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital 399 Bathurst Street Toronto ON M5T 2S8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sammartino","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital 399 Bathurst Street Toronto ON M5T 2S8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Toronto Western Hospital 399 Bathurst Street Toronto ON M5T 2S8 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kullervo","family":"Hynynen","sequence":"additional","affiliation":[{"name":"Physical Sciences Sunnybrook Research Institute 2075 Bayview Avenue Toronto ON M4N 3M5 Canada"},{"name":"Department of Medical Biophysics University of Toronto 101 College Street Toronto ON M5G 1L7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70048-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300962"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.3.JNS142592"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.2.r00au42517"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22059"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3808"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20060"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2010.534527"},{"key":"e_1_2_7_11_1","unstructured":"HuangY LipsmanN SchwartzML et\u00a0al.Correlation of Lesion Size to Thermal Dose Measured by MR Thermometry in MR\u2010Guided Focused Ultrasound for the Treatment of Essential Tremor. 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