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The purpose of this study is to present a novel delivery system (AIM\u2010Brachy) design that can enable dynamic\u2010shield IMBT for prostate cancer.<\/jats:p><\/jats:sec>Methods<\/jats:title>The AIM\u2010Brachy system dynamically controls the rotation of platinum shields, placed within interstitial catheters, which partially collimate the radiation emitted from an 169<\/jats:sup>Yb source. Conventional HDR BT (10\u00a0Ci 192<\/jats:sup>Ir) and IMBT (18\u00a0Ci 169<\/jats:sup>Yb) plans were generated for 12 patients using an in\u2010house column generation\u2010based optimizer, coupled to a Geant4\u2010based dose calculation engine, RapidBrachyMC. Treatment plans were normalized to match the same PTV D90<\/jats:sub><\/jats:italic> coverage as the clinical plan. Intershield attenuation effects were taken into account. A sensitivity analysis was performed to evaluate the dosimetric impact of systematic longitudinal source positioning errors (1\u00a0mm, 2\u00a0mm, and 3\u00a0mm) and rotational errors (5, 10 and 15) on clinically relevant parameters (PTV D90<\/jats:sub><\/jats:italic> and urethra D10<\/jats:sub><\/jats:italic>).<\/jats:p><\/jats:sec>Results<\/jats:title>The platinum shield reduced the dose rate on the shielded side at 1\u00a0cm to 18.1% of the dose rate on the unshielded side. For equal PTV D90<\/jats:sub><\/jats:italic> coverage, the urethral D10<\/jats:sub><\/jats:italic> was reduced by 13.3%\u00a0\u00a04.7%, without change to other plan quality indices (PTV V100<\/jats:sub><\/jats:italic>, V150,<\/jats:sub> V200<\/jats:sub><\/jats:italic>, bladder V75<\/jats:sub><\/jats:italic>, rectum V75<\/jats:sub><\/jats:italic>, HI, COIN). Delivery times for HDR BT and IMBT were 9.2\u00a0\u00b1\u00a01.6\u00a0min and 18.6\u00a0\u00b1\u00a04.0\u00a0min, respectively. In general, the PTV D90<\/jats:sub><\/jats:italic> was more sensitive to source positioning errors than rotational errors, while the urethral D10<\/jats:sub><\/jats:italic> was more sensitive to rotational errors than source positioning errors. For a typical range of positioning errors (1\u00a0mm, 5), the overall tolerance was <2%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The AIM\u2010Brachy system was proposed to deliver dynamic\u2010shield IMBT for prostate cancer with the potential to create a low dose tunnel within the urethra. The urethra\u2010sparing properties are desirable to minimize the occurrence and severity of urethral strictures or, alternatively, to provide a method for dose escalation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.13959","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T08:41:44Z","timestamp":1576140104000},"page":"859-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A novel 169<\/sup>Yb\u2010based dynamic\u2010shield intensity modulated brachytherapy delivery system for prostate cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"Gabriel","family":"Famulari","sequence":"first","affiliation":[{"name":"Medical Physics Unit McGill University Montr\u00e9al Qu\u00e9bec H4A 3J1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Duclos","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University 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