{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:14:38Z","timestamp":1778825678205,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To present our preliminary experience with the recently released Calypso lung beacons to track lung tumor location during stereotactic body radiation therapy (SBRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>Five recent lung SBRT patients had Calypso lung beacons implanted for tumor tracking during treatment. Beacons were placed by a pulmonologist using fluoroscopic navigation within 1 week prior to planning four\u2010dimensional computed tomography (4DCT) acquisition. Patients were immobilized in a full\u2010body double\u2010vacuum bag. For the first three patients, a verification 4DCT was obtained prior to the first fraction with the patient in the treatment position to assess both beacon migration and motion of tumor and beacons relative to planning day. For each treatment fraction, Calypso was used to position the patient. A verification cone\u2010beam CT (CBCT) confirmed the Calypso\u2010defined target position was appropriate. Real\u2010time Calypso tracking information was also acquired and compared to an action level that was used to determine if the tumor migrated outside of the planning target volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For four patients, the implant procedure was well tolerated, with average CBCT\u2010based shifts being within 0.2\u00a0mm of the shifts reported by Calypso at the time of imaging. The other patient had a small pneumothorax due to very peripheral tumor location and experienced beacon migration. However, the patient quickly recovered from the pneumothorax, and after deactivating that beacon, motion tracking was possible throughout his treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All patients were successfully treated with SBRT using the newly released Calypso lung beacons, with initial positioning confirmed by this clinic's current clinical standard of CBCT. The system allowed us to validate, with real\u2010time confirmation, that the planned internal target volumes were appropriate to each day's extent of actual tumor motion. An efficient and effective workflow for utilizing the new lung beacons for SBRT treatments was developed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.14300","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T20:40:07Z","timestamp":1590698407000},"page":"4407-4415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preliminary clinical experience with Calypso anchored beacons for tumor tracking in lung SBRT"],"prefix":"10.1002","volume":"47","author":[{"given":"Vikren","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Paxton","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prema","family":"Rassiah\u2010Szegedi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakravarthy B.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying J.","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine E.","family":"Kokeny","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bill J.","family":"Salter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Utah Salt Lake City UT 84112 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_9_3_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132016","author":"Howlader N","year":"2019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.07.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.261"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1481292"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.07.2278"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00154-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00056-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.08.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.027"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01455-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.01.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.09.004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.11.066"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2009.03.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600917161"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1398037"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.030"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.1352"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.025"},{"key":"e_1_2_9_25_1","article-title":"Anchored Transponder Guided Lung Radiation Therapy","author":"Dobelbower MC","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318260e00d"},{"key":"e_1_2_9_27_1","volume-title":"Calypso Beacon Care Package \u2010 Lung Instructions for Use","author":"Varian Medical Systems","year":"2018"},{"key":"e_1_2_9_28_1","unstructured":"Varian Medical Systems Calypso \u00ae System Lung Usage Guide;2016."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.07.2260"}],"updated-by":[{"DOI":"10.1002\/mp.14376","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000}}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmp.14300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.14300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mp.14300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.14300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:45:41Z","timestamp":1693813541000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/mp.14300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/mp.14300"],"URL":"https:\/\/doi.org\/10.1002\/mp.14300","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/mp.14376","asserted-by":"object"}]},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,25]]},"assertion":[{"value":"2019-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}