{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T09:47:25Z","timestamp":1767260845731},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This paper describes and experimentally validates a methodology for improving contrast and spatial resolution of the x\u2010ray dark\u2010field imaging (XDFI) by cutting the monochromator\u2010collimator asymmetrically and thinning the Laue angle analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measure the spatial resolution of our XDFI setup using a test object consisting of wolfram tungsten meshes and compare it with the theoretical prediction. Using x\u2010ray dark\u2010field computed tomography of breast cancer specimens (lobular carcinoma in situ), we demonstrate that the resolution of XDFI is sufficient for histopathologic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our experimental results show that the overall spatial resolution of XDFI can be improved by approximately a factor of 2 when these modifications are implemented. The reconstructed images of breast cancer specimens provide sufficient details for radiologic histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By cutting the monochromator\u2010collimator and thinning the Laue angle analyzer, XDFI can achieve the resolution sufficient for radiologic histopathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.14442","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T12:31:54Z","timestamp":1596889914000},"page":"5505-5513","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improving contrast and spatial resolution in crystal analyzer\u2010based x\u2010ray dark\u2010field imaging: Theoretical considerations and experimental demonstration"],"prefix":"10.1002","volume":"47","author":[{"given":"Masami","family":"Ando","sequence":"first","affiliation":[{"name":"Photon Factory KEK Oho 1\u20101 Tsukuba Ibaraki 305\u20100801 Japan"},{"name":"Research Institute of Science and Engineering Tokyo University of Science Noda Chiba 278\u20108510 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nakao","sequence":"additional","affiliation":[{"name":"Research Institute of Science and Engineering Tokyo University of Science Noda Chiba 278\u20108510 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Jin","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Kyushu Institute of Technology Kitakyushu 804\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Photon Factory KEK Oho 1\u20101 Tsukuba Ibaraki 305\u20100801 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sunaguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Nagoya University 1\u20101\u201020 Daiko\u2010Minami, Higashi\u2010Ku Nagoya Aichi 461\u20108673 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjin","family":"Sung","sequence":"additional","affiliation":[{"name":"University of Wisconsin Milwaukee WI 53211 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Kyushu Institute of Technology Kitakyushu 804\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Kyushu Institute of Technology Kitakyushu 804\u20108550 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Shingijutsu Kyokai (Society of New Technology) Yushima Bunkyo, Tokyo 113\u20100034 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Kawashima","sequence":"additional","affiliation":[{"name":"University of Technology Katakura 1404\u20101 Hachioji Tokyo 192\u20100914 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yuasa","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering and Science Yamagata University 4\u20103\u201016 Jyonan Yonezawa Yamagata 992\u20108510 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensaku","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Media Science Graduate School of Information Science Nagoya University Nagoya Aichi 464\u20108601 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Clinical Research Center Department of Pathology Nagoya Medical Center Nagoya Aichi 460\u20100001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston MA 01778 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.41.L1016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.43.L1175"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1891305"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.44.L528"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.22.002622"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.001818"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"2D and 3D visualization of ductal carcinoma in situ (DCIS) due to x\u2010ray refraction contrast","volume":"14","author":"Ando M","year":"2006","journal-title":"Bioimages"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.45.L740"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nima.2008.03.092"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0528-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.36.000391"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3635784"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-0221\/8\/05\/C05001"},{"key":"e_1_2_7_15_1","first-page":"3021","article-title":"X\u2010ray phase contrast imaging in the dark field: implementation and evaluation using excised tissue specimens","volume":"23","author":"Ando M","year":"2013","journal-title":"Eur Radiol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4824075"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/42\/11\/001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198528920.001.0001"},{"key":"e_1_2_7_19_1","volume-title":"X\u2010Ray Scattering and Synchrotron Radiation Science Basic (in Japanese)","author":"Kikuta S","year":"2011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.52.872"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0365110X62003473"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1143\/JPSJ.26.1239"},{"key":"e_1_2_7_23_1","first-page":"469","article-title":"Dynamic theory of x\u2010ray diffraction in crystals","volume":"87","author":"Taupin D","year":"1964","journal-title":"Bull Soc Fr Mineral Crystallogr"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3651144"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03792.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncr157"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmp.14442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.14442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mp.14442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.14442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:01:51Z","timestamp":1693544511000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/mp.14442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/mp.14442"],"URL":"https:\/\/doi.org\/10.1002\/mp.14442","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"assertion":[{"value":"2020-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}