{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:40:32Z","timestamp":1693658432504},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The goal of the current study was to investigate the impact of different computational models on <jats:sup>131<\/jats:sup>I dosimetry prior to hyperthyroidism therapy. It was also aimed to highlight an accurate and cost\u2010effective method for routine dosimetry of graves and toxic adenoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 45 patients was recruited in the current study with Graves (n\u00a0=\u00a030) and Toxic Adenoma (n\u00a0=\u00a015) diseases. The eligibility criterion was determined using the patients\u2019 blood test, <jats:sup>99m<\/jats:sup>Tc\u2010 pertechnetate scintigraphy, and ultrasound scan. A properly calibrated thyroid probe equipped with sodium iodide crystal [NaI(Tl)] was used to obtain the uptake measurements at 2, 24, 48, 72, and 96\u00a0h following administration of 0.27\u20130.73\u00a0MBq <jats:sup>131<\/jats:sup>I tracer. The absorbed radiation dose of the thyroid gland\/nodule was calculated by three different methods. The calculation models were based on the time\u2010integrated activity (recommended by MIRD), effective half\u2010life (recommended by EANM), and ellipsoidal\u2010shape assumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean effective half\u2010life was 138\u00a0\u00b1\u00a041\u00a0h and 110\u00a0\u00b1\u00a048\u00a0h in Graves and Toxic Adenoma patients, respectively. The mean residence time was 125\u00a0\u00b1\u00a05\u00a0h in Graves patients, while it was 93\u00a0\u00b1\u00a055\u00a0h in Toxic Adenoma. The amount of <jats:sup>131<\/jats:sup>I activity required to deliver 200\u00a0Gy to the thyroid gland in Graves patients was calculated as 436\u00a0\u00b1\u00a0381\u00a0MBq, 426\u00a0\u00b1\u00a0370\u00a0MBq, and 488\u00a0\u00b1\u00a0455\u00a0MBq according to MIRD, EANM, and ellipsoidal\u2010shape model, respectively. However, the activity required to impart 300\u00a0Gy in the toxic nodules was computed as 622\u00a0\u00b1\u00a0332\u00a0MBq by MIRD, 907\u00a0\u00b1\u00a0588\u00a0MBq by EANM, and 1060\u00a0\u00b1\u00a0639\u00a0MBq by the ellipsoidal\u2010shape model. Overall, no significant difference was found between the MIRD and both of the EANM and ellipsoidal\u2010shape models in the Graves patients (R<jats:sup>2<\/jats:sup>\u00a0=\u00a00.99, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In contrast, less agreement (R<jats:sup>2<\/jats:sup>\u00a0=\u00a00.86) was shown between EANM and MIRD in Toxic Adenoma patients with no statistically significant difference (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05), while the difference was significant (P<jats:sub>value<\/jats:sub><jats:bold>\u00a0&lt;\u00a0<\/jats:bold>0.05) between the MIRD and the ellipsoidal\u2010shape model with moderate association (R<jats:sub>2<\/jats:sub>\u00a0=\u00a00.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was deduced that the effective half\u2010life\u2010based model (EANM model) is a successful and affordable method for performing dosimetry in Graves patients. While, unit density sphere model sounds the most appropriate approach to be used in Toxic Adenoma dosimetry. However, using the ellipsoidal\u2010shape assumption in the thyroid gland\/or nodule dose calculation leads to redundantly larger activity administration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.14478","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T06:26:57Z","timestamp":1600928817000},"page":"5810-5816","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of different computational assumptions in <sup>131<\/sup>I dosimetry for hyperthyroidism therapy"],"prefix":"10.1002","volume":"47","author":[{"given":"Mohammad","family":"Abuqbeitah","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department Istanbul University\u2010Cerrahpasa Cerrahpasa Medical School Istanbul Fatih 0090 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sait","family":"Sa\u011fer","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department 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