{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:14:02Z","timestamp":1774156442693,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To present a system for the treatment of prostate cancer in a single\u2010fraction regimen using <jats:sup>169<\/jats:sup>Yb\u2010based rotating shield brachytherapy (RSBT) with a single\u2010catheter robotic delivery system. The proposed system is innovative because it can deliver RSBT through multiple implanted needles independently, in serial, using flexible catheters, with no inter\u2010needle shielding effects and without the need to rotate multiple shielded catheters inside the needles simultaneously, resulting in a simple, mechanically robust, delivery approach. RSBT was compared to conventional <jats:sup>192<\/jats:sup>Ir\u2010based high\u2010dose\u2010rate brachytherapy (HDR\u2010BT) in a treatment planning study with dose escalation and urethral sparing goals, representing single\u2010fraction brachytherapy monotherapy and brachytherapy as a boost to external beam radiotherapy, respectively. A prototype mechanical delivery system was constructed and quantitatively evaluated as a proof of concept.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment plans for twenty\u2010six patients with single fraction prescriptions of 20.5 and 15\u00a0Gy, were created for dose escalation and urethral sparing, respectively. The RSBT and HDR\u2010BT delivery systems were modeled with one partially shielded 999\u00a0GBq (27\u00a0Ci) <jats:sup>169<\/jats:sup>Yb source and one 370\u00a0GBq (10\u00a0Ci) <jats:sup>192<\/jats:sup>Ir source, respectively. A prototype angular drive system for helical source delivery was constructed. Mechanical accuracy measurements of source translational position and angular orientation in a simulated treatment delivery setup were obtained using the prototype system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For dose escalation, with equivalent urethra <jats:italic>D<\/jats:italic><jats:sub>10%<\/jats:sub>, PTV <jats:italic>D<\/jats:italic><jats:sub>90%<\/jats:sub> for RSBT vs HDR\u2010BT increased from 22.6\u00a0\u00b1\u00a00.0\u00a0Gy (average\u00a0\u00b1\u00a0standard deviation) to 29.3\u00a0\u00b1\u00a00.9\u00a0Gy, or 29.9 %\u00a0\u00b1\u00a03.0%, with treatment times of 51.4\u00a0\u00b1\u00a06.1\u00a0min for RSBT and 15.8\u00a0\u00b1\u00a02.3\u00a0min for 10\u00a0Ci <jats:sup>192<\/jats:sup>Ir\u2010based HDR\u2010BT. For urethra sparing, with equivalent PTV <jats:italic>D<jats:sub>90<\/jats:sub><\/jats:italic><jats:sub>%<\/jats:sub>, urethra <jats:italic>D<\/jats:italic><jats:sub>10%<\/jats:sub> for RSBT vs HDR\u2010BT decreased for RSBT vs HDR\u2010BT from 15.6\u00a0\u00b1\u00a00.4\u00a0Gy to 12.0\u00a0\u00b1\u00a00.4\u00a0Gy, or 23.1% \u00b1 3.5%, with treatment times of 30.0\u00a0\u00b1\u00a03.7\u00a0min for RSBT and 12.3\u00a0\u00b1\u00a01.8\u00a0min for HDR\u2010BT. Differences between measured vs predicted rotating catheter positions (corresponding to source position) were within 0.18\u00a0mm\u00a0\u00b1\u00a00.12\u00a0mm longitudinally and 0.07\u00b0 \u00b1 0.78\u00b0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>169<\/jats:sup>Yb\u2010based RSBT can increase PTV <jats:italic>D<\/jats:italic><jats:sub>90%<\/jats:sub> or decrease urethral <jats:italic>D<\/jats:italic><jats:sub>10%<\/jats:sub> relative to HDR\u2010BT with treatment times of less than 1\u00a0h using a single\u2010source robotic delivery system with treatment delivered in a single fraction. The prototype helical delivery system was able to demonstrate adequate mechanical accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.14533","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T07:52:47Z","timestamp":1602661967000},"page":"6430-6439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<sup>169<\/sup>Yb\u2010based rotating shield brachytherapy for prostate cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"Quentin","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Iowa 200 Hawkins Drive Iowa City Iowa 52242 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolyn M.","family":"Hopfensperger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Iowa 1402 Seamans Center for the Engineering Arts and Sciences Iowa City Iowa 52242 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