{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:24:37Z","timestamp":1758893077081},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010CE\u201018\u20100003"],"award-info":[{"award-number":["ANR\u201015\u2010CE\u201018\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to perform dosimetry for [<jats:sup>99m<\/jats:sup>Tc]NTP15\u20105 radiotracer used in imaging of articular cartilage in rabbits and humans. The radiotracer (covered by a world patent WO 01\/00621 A1) has been proposed in the previous years for the study of cartilage in osteoarthritis diseases. A sensitive imaging approach is essential to quantify osteoarthritis progression and monitor response to new therapies. [<jats:sup>99m<\/jats:sup>Tc]NTP15\u20105 binds to cartilage proteoglycans whose decreased content is associated to a loss of biomedical function of cartilage. We have implemented the whole dosimetry study concerning this new radiotracer for rabbits and humans using the GATE Monte Carlo platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Absorbed doses to critical organs are determined using the MIRD formalism. Biodistribution data are obtained by organ sampling, measuring the activity in organs for three rabbits sacrificed at various times postadministration, and by SPECT\/CT imaging at different times after injection. Most important sources are cartilages (in knees and intervertebral discs), due to localization together with the liver and kidneys due to excretion of the agent. S\u2010values are calculated from rabbit\u2019s CT scan and human CT scan using the GATE v8.0 Monte Carlo platform. Cumulated activity in humans is extrapolated from animals using the %kg\u2010dose\/g method. Particular attention is given to dose calculation in bones, bone marrow and organs at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dosimetry performed in rabbits shows highest absorbed doses for liver and kidneys with respectively 22.5 and 43.8\u00a0\u00b5Gy per MBq of injected activity. In humans, we found absorbed doses for a maximum injected activity of 15\u00a0MBq\/kg, that is, 1050\u00a0MBq for an adult of 70\u00a0kgs of 9.03\u00a0mGy for kidneys and 4.16\u00a0mGy for knee cartilages. Effective dose is 2.69\u00a0\u00b5Sv\/MBq.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The dosimetry profile of [<jats:sup>99m<\/jats:sup>Tc]NTP15\u20105 in the context of preclinical trials is of major importance in order to make sure that organs at risk are not overexposed. GATE provides all the capability needed to calculate dose profiles for internal dosimetry. The extrapolation of the dose for a human model is a first step towards clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.14603","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T06:47:30Z","timestamp":1605941250000},"page":"477-487","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Internal dosimetry of [<sup>99m<\/sup>Tc]NTP15\u20105 radiotracer for cartilage imaging in preclinical and clinical models using the GATE Monte Carlo platform"],"prefix":"10.1002","volume":"48","author":[{"given":"Giovanna Rosa","family":"Fois","sequence":"first","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne CNRS\/IN2P3 Laboratoire de Physique de Clermont UMR6533 4 avenue Blaise Pascal TSA 60026 CS Clermont\u2010Ferrand Aubi\u00e8re cedex 60026 63178 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9mence","family":"Valla","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques UMR1240 58 Rue Montalembert Clermont\u2010Ferrand cedex 63 005 France"},{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Jouberton","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques UMR1240 58 Rue Montalembert Clermont\u2010Ferrand cedex 63 005 France"},{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Sas","sequence":"additional","affiliation":[{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Billoux","sequence":"additional","affiliation":[{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Auzeloux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques UMR1240 58 Rue Montalembert Clermont\u2010Ferrand cedex 63 005 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Cachin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques UMR1240 58 Rue Montalembert Clermont\u2010Ferrand cedex 63 005 France"},{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Miot\u2010Noirault","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne INSERM Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques UMR1240 58 Rue Montalembert Clermont\u2010Ferrand cedex 63 005 France"},{"name":"Centre Jean Perrin Clermont\u2010Ferrand 63011 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Maigne","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Clermont Auvergne CNRS\/IN2P3 Laboratoire de Physique de Clermont UMR6533 4 avenue Blaise Pascal TSA 60026 CS Clermont\u2010Ferrand Aubi\u00e8re cedex 60026 63178 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.suppl_2.ii79"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-002-8400-3"},{"key":"e_1_2_6_5_1","unstructured":"MadelmontJC GiraudI NicolasC et al.inventors. 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