{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:19:40Z","timestamp":1790713180489,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCI R01CA235564"],"award-info":[{"award-number":["NCI R01CA235564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NCI R01CA221971"],"award-info":[{"award-number":["NCI R01CA221971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Colorectal cancer is the third most common form of cancer in the United States, and up to 60% of these patients develop liver metastasis. While hepatic resection is the curative treatment of choice, only 20% of patients are candidates at the time of diagnosis. While percutaneous thermal ablation (PTA) has demonstrated 24%\u201351% overall 5\u2010year survival rates, assurance of sufficient ablation margin delivery (5\u00a0mm) can be challenging, with current methods of 2D distance measurement not ensuring 3D minimum margin. We hypothesized that biomechanical model\u2010based deformable image registration (DIR) can reduce spatial uncertainties and differentiate local tumor progression (LTP) patients from LTP\u2010free patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively acquired 30 patients (16 LTP and 14 LTP\u2010free) at our institution who had undergone PTA and had a contrast\u2010enhanced pre\u2010treatment and post\u2010ablation CT scan. Liver, disease, and ablation zone were manually segmented. Biomechanical model\u2010based DIR between the pre\u2010treatment and post\u2010ablation CT mapped the gross tumor volume onto the ablation zone and measured 3D minimum delivered margin (MDM). An in\u2010house cone\u2010tracing algorithm determined if progression qualitatively collocated with insufficient 5\u00a0mm margin achieved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mann\u2013Whitney U test showed a significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) in MDM from the LTP and LTP\u2010free groups. A total of 93% (13\/14) of patients with LTP had a correlation between progression and missing 5\u00a0mm of margin volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Biomechanical DIR is able to reduce spatial uncertainty and allow measurement of delivered 3D MDM. This minimum margin can help ensure sufficient ablation delivery, and our workflow can provide valuable information in a clinically useful timeframe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.15147","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T03:23:37Z","timestamp":1627961017000},"page":"6226-6236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A novel use of biomechanical model\u2010based deformable image registration (DIR) for assessing colorectal liver metastases ablation outcomes"],"prefix":"10.1002","volume":"48","author":[{"given":"Brian M.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"The University of Texas Graduate School of Biomedical Sciences at Houston Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Mao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cazoulat","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kyle Jones","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno C.","family":"Odisio","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy K.","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO Biennial Report 2012\u20102013. 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