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The primary purpose is to characterize breast tumors based on their dielectric properties. Early detection of high\u2010risk lesions and increasing the accuracy of tumor sampling and pathological diagnosis are secondary objectives of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The tumor detection probe (TDP) was first applied to the mouse model for electrical safety evaluations by electrical current measurement. Then it was utilized for characterization of 138 human palpable breast lesions that were to undergo core needle biopsy (CNB), vacuum\u2010assisted biopsy (VAB), or fine needle aspiration (FNA) on the surgeon's requests. Impedance phase slope (IPS) in frequency ranges of 100\u2013 500\u00a0kHz and impedance magnitude in f\u00a0=\u00a01\u00a0kHz were extracted as the classification parameters. Consistency of radiological and pathological declarations for the excisional recommendation was then compared with the IPS values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Considering pathological results as the gold standard, meaningful correlations between IPS and pathophysiological status of lesions recommended for excision (such as atypical ductal hyperplasia, papillary lesions, complex sclerosing adenosis, and fibroadenoma) were observed (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). These pathophysiological properties may include cell size, membrane permeability, packing density, adenosis, cytoplasm structure, etc. Benign breast lesions showed IPS values greater than 0, while high\u2010risk proliferative, precancerous, or cancerous lesions had negative IPS values. Statistical analysis showed 95% sensitivity with area under the curve (AUC) equal to 0.92.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Borderline breast diseases and high\u2010risk lesions that should be excised according to standard guidelines can be diagnosed with TDP before any sampling process. It is an important outcome for high\u2010risk lesions that are radiologically underestimated to BI\u2010RADS3, specifically in younger patients with dense breast masses that present challenges in mammographic and sonographic evaluations. Also, the lowest IPS value detects the most pathologic portions of the tumor for increasing sampling accuracy in large tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Precise detection of high\u2010risk breast masses, which may be declared BI\u2010RADS3 instead of BI\u2010RADS4a<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.15481","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T12:43:15Z","timestamp":1643805795000},"page":"2746-2760","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intraradiological pathology\u2010calibrated electrical impedance spectroscopy in the evaluation of excision\u2010required breast lesions"],"prefix":"10.1002","volume":"49","author":[{"given":"Reihane","family":"Mahdavi","sequence":"first","affiliation":[{"name":"Nano Bioelectronics Devices Lab Cancer Electronics Research Group School of Electrical and Computer 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