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Ultrasound imaging is a crucially important tool for the diagnosis of this disease. Based on ultrasonic manifestations, hepatic echinococcosis can be classified into many subtypes. However, subtyping is nontrivial due to the challenges of complex sonographic textures and large intraclass and small interclass differences. The purpose of this study is to develop a computer\u2010aided diagnosis system for hepatic echinococcosis based on ultrasound images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected a multicenter ultrasound dataset containing 9112 images from 5028 patients who were diagnosed with hepatic echinococcosis (the largest cohort to date) and developed a two\u2010stage multiresolution neural network for the automatic diagnosis of hepatic echinococcosis into nine subtypes, as suggested by the WHO. Our method was based on YOLO3 with two additional strategies to improve its performance: coarse grouping and multiresolution sampling. Considering that some subtypes are inherently very similar and difficult to differentiate; in the first stage, we detected and classified lesions into four coarse groups instead of making a direct classification into nine classes. In the second stage, we performed fine\u2010grained classification within each coarse group. Multiple views with different resolutions were sampled from the detected lesions and were input into Darknet53. The softmax outputs for the multiresolution views were averaged to generate the final output.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the proposed coarse grouping and multiresolution sampling strategies proved to be effective and improved the classification performance by a large margin compared with the setting without using the two strategies. Using fivefold cross\u2010validation, our method achieved 87.1%, 86.2%, and 86.5% in the average recall, precision and F1\u2010score, respectively, and outperformed other state\u2010of\u2010the\u2010art methods remarkably.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The experimental results demonstrate the great promise of our method for classifying hepatic echinococcosis. Our method can be used as an effective tool to facilitate large\u2010scale screening for hepatic echinococcosis in high\u2010risk, resource\u2010poor areas, thus contributing to the early diagnosis of this disease and resulting in more successful treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.15548","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T12:34:39Z","timestamp":1645533279000},"page":"3199-3212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A two\u2010stage multiresolution neural network for automatic diagnosis of hepatic echinococcosis from ultrasound images: A multicenter study"],"prefix":"10.1002","volume":"49","author":[{"given":"Jun","family":"Cheng","sequence":"first","affiliation":[{"name":"National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University  Shenzhen China"},{"name":"Medical Ultrasound Image Computing (MUSIC) Laboratory Shenzhen University  Shenzhen China"},{"name":"Marshall Laboratory of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Shenzhen Luohu Hospital Group Luohu People's Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University  Shenzhen China"},{"name":"Medical Ultrasound Image Computing (MUSIC) Laboratory Shenzhen University  Shenzhen China"},{"name":"Marshall Laboratory of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Electronic &amp; Computer Engineering the Hong Kong University of Science and Technology  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhou","sequence":"additional","affiliation":[{"name":"National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University  Shenzhen China"},{"name":"Medical Ultrasound Image Computing (MUSIC) Laboratory Shenzhen University  Shenzhen China"},{"name":"Marshall Laboratory of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University  Shenzhen China"},{"name":"Medical Ultrasound Image Computing (MUSIC) Laboratory Shenzhen University  Shenzhen China"},{"name":"Marshall Laboratory of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University  Shenzhen China"},{"name":"Medical Ultrasound Image Computing (MUSIC) Laboratory Shenzhen University  Shenzhen China"},{"name":"Marshall Laboratory of Biomedical Engineering Shenzhen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Shenzhen MGI Tech Co., Ltd.  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