{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:10:26Z","timestamp":1788545426984,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Accurate preoperative diagnosis of parotid tumor is essential for the formulation of optimal individualized surgical plans. The study aims to investigate the diagnostic performance of radiomics nomogram based on contrast\u2010enhanced computed tomography (CT) images in the differentiation of the two most common benign parotid gland tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and ten patients with parotid gland tumors including 76 with pleomorphic adenoma (PA) and 34 with adenolymphoma (AL) confirmed by histopathology were included in this study. Radiomics features were extracted from contrast\u2010enhanced CT images of venous phase. A radiomics model was established and a radiomics score (Rad\u2010score) was calculated. Clinical factors including clinical data and CT features were assessed to build a clinical factor model. Finally, a nomogram incorporating the Rad\u2010score and independent clinical factors was constructed. Receiver operator characteristics (ROC) curve was generated and the area under the ROC curve (AUC) was calculated to quantify the discriminative performance of each model on both the training and validation cohorts. Decision curve analysis (DCA) was conducted to evaluate the clinical usefulness of each model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The radiomics model showed good discrimination in the training cohort [AUC, 0.89; 95% confidence interval (CI), 0.80\u20130.98] and validation cohort (AUC, 0.89; 95% CI, 0.77\u20131.00). The radiomics nomogram showed excellent discrimination in the training cohort (AUC, 0.98; 95% CI, 0.96\u20131.00) and validation cohort (AUC, 0.95; 95% CI, 0.88\u20131.00) and displayed better discrimination efficacy compared with the clinical factor model (AUC, 0.93; 95% CI, 0.88\u20130.99) in the training cohort (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The DCA demonstrated that the combined radiomics nomogram provided superior clinical usefulness than clinical factor model and radiomics model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CT\u2010based radiomics nomogram combining Rad\u2010score and clinical factors exhibits excellent predictive capability for differentiating parotid PA from AL, which might hold promise in assisting radiologists and clinicians in the exact differential diagnosis and formulation of appropriate treatment strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.16042","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T08:44:07Z","timestamp":1666514647000},"page":"947-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Development and validation of CT\u2010based radiomics nomogram for the classification of benign parotid gland tumors"],"prefix":"10.1002","volume":"50","author":[{"given":"Menglong","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Kunshan Third People's Hospital  Kunshan Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Ge","sequence":"additional","affiliation":[{"name":"GE Healthcare China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexue","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.1.r00jl4519"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2017.04.003"},{"issue":"9","key":"e_1_2_9_4_1","first-page":"1757","article-title":"Earring lesions of the parotid tail","volume":"24","author":"Hamilton BE","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418501127346305"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"129","article-title":"Survey of opinions on the management of pleomorphic adenoma among United Kingdom oral and maxillofacial surgeons","volume":"20","author":"Tarakji B","year":"2010","journal-title":"J Ear Nose Throat"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199407000-00004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80295-2"},{"key":"e_1_2_9_9_1","unstructured":"KwonKH SuhJH HurMH ChungWY KangHY ParkCS.Enucleation for the management of the parotid Warthin's tumor. 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