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Such measurements are particularly important for heavy\u2010ion beam cancer therapy. On this basis, the present work examined the high LET effect associated with three\u2010dimensional gel dosimetry based on radiation\u2010induced chemical reactions. The purpose of this study was to create an ion beam radio\u2010fluorogenic gel dosimeter with a reduced effect of LET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nanoclay radio\u2010fluorogenic gel (NC\u2010RFG) dosimeters were prepared, typically containing 100\u00a0\u03bcM dihydrorhodamine 123 (DHR123) and 2.0\u00a0wt% nanoclay together with catalytic additives promoting Fenton or Fenton\u2010like reactions. The radiological properties of NC\u2010RFG dosimeters having different compositions in response to a carbon\u2010ion beam were investigated using a fluorescence gel scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An NC\u2010RFG dosimeter capable of generating a fluorescence intensity distribution reflecting the carbon\u2010ion beam dose profile was obtained. It was clarified that the reduction of the unfavorable LET dependence results from an acceleration of the reactions between DHR123 and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which is a molecular radiolysis product. The effects of varying the preparation conditions on the radiological properties of these gels were also examined. The optimum H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> catalyst was determined to include 1\u00a0mM Fe<jats:sup>3+<\/jats:sup> ions, and the addition of 100\u00a0mM pyridine was also found to increase the sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This technique allows the first\u2010ever evaluation of the depth\u2013dose profile of a carbon\u2010ion beam at typical therapeutic levels of several Gy without LET effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.16092","type":"journal-article","created":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T15:24:12Z","timestamp":1667748252000},"page":"1073-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Radio\u2010fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon\u2010ion beam 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